Laboratoire de Tribologie et Dynamique des Systèmes, CNRS UMR 5513, Université de Lyon, Ecole Centrale de Lyon, France.
Laboratoire de Tribologie et Dynamique des Systèmes, CNRS UMR 5513, Université de Lyon, Ecole Centrale de Lyon, France; Université de Lyon, Université Claude Bernard Lyon 1, ISPB-Faculté de Pharmacie, Lyon, France.
Med Eng Phys. 2024 Sep;131:104225. doi: 10.1016/j.medengphy.2024.104225. Epub 2024 Aug 20.
Intracranial aneurysm is a major health issue related to biomechanical arterial wall degradation. Currently, no method allows predicting rupture risk based on in vivo quantitative mechanical data. This work is part of a large-scale project aimed at providing clinicians with a non-invasive patient-specific decision support tool, based on the in vivo mechanical characterisation of the aneurysm wall. Thus, the primary objective of the project was to develop a deformation device prototype (DDP) of the artery wall and to calibrate it on polymeric phantom arteries. The deformations induced on the phantom arteries were quantified experimentally using a Digital Image Correlation (DIC) system. The results indicated that the DIC system was able to measure the small displacements generated by the DDP. We also observed that the flow mimicking the blood flow did not significantly disturb the measurements of the artery wall displacement caused by the DDP. Finally, a limit displacement value generated by the DDP was evaluated. This value corresponds to the lowest displacement value detectable by the clinical imaging system that will be tested on animals in the future (Spectral Photon Counting CT).
颅内动脉瘤是与动脉壁生物力学降解有关的一个主要健康问题。目前，尚无方法能够基于活体定量力学数据来预测破裂风险。这项工作是一个大型项目的一部分，旨在为临床医生提供一种基于动脉瘤壁活体力学特性的非侵入性个体化决策支持工具。因此，该项目的主要目标是开发一种动脉壁变形装置原型（DDP），并在聚合物模拟动脉上对其进行校准。使用数字图像相关（DIC）系统对模拟动脉上产生的变形进行了实验量化。结果表明，DIC 系统能够测量 DDP 产生的小位移。我们还观察到，模拟血流不会显著干扰由 DDP 引起的动脉壁位移的测量。最后，评估了 DDP 产生的极限位移值。该值对应于未来将在动物身上进行测试的临床成像系统能够检测到的最低位移值（光谱光子计数 CT）。
