Raviol J, Plet G, Langlois J B, Si-Mohamed S, Magoariec H, Pailler-Mattei C
Ecole Centrale de Lyon, CNRS, ENTPE, LTDS, UMR 5513, Écully 69130, France.
CERMEP - Imagerie du Vivant, Bron 69500, France.
R Soc Open Sci. 2024 Apr 17;11(4):231936. doi: 10.1098/rsos.231936. eCollection 2024 Apr.
Intracranial aneurysm is a pathology related to the deterioration of the arterial wall. This work is an essential part of a large-scale project aimed at providing clinicians with a non-invasive patient-specific decision support tool to facilitate the rupture risk assessment. It will lean on the link between the aneurysm shape clinically observed and a database derived from the mechanical characterization of aneurysms. To supply this database, a deformation device prototype of the arterial wall was developed. Its use coupled with medical imaging (spectral photon-counting computed tomography providing a spatial resolution down to 250 μm) is used to determine the mechanical properties of the wall based on the inverse analysis of the quantification of the wall deformation observed experimentally. This study presents the application of this original procedure to an animal model of aneurysm. The mechanical properties of the aneurysm wall identified were consistent with the literature, and the errors between the numerical and experimental results were less than 10%. Based on these parameters, this study allows the assessment of the aneurysm stress state for a known solicitation and points towards the definition of a rupture criterion.
颅内动脉瘤是一种与动脉壁退变相关的病变。这项工作是一个大型项目的重要组成部分，该项目旨在为临床医生提供一种针对特定患者的非侵入性决策支持工具，以促进破裂风险评估。它将依赖于临床观察到的动脉瘤形状与源自动脉瘤力学特性的数据库之间的联系。为了提供这个数据库，开发了一种动脉壁变形装置原型。将其与医学成像（光谱光子计数计算机断层扫描，空间分辨率低至250μm）结合使用，基于对实验观察到的壁变形量化的逆分析来确定壁的力学性能。本研究展示了这一原始程序在动脉瘤动物模型中的应用。所确定的动脉瘤壁力学性能与文献一致，数值结果与实验结果之间的误差小于10%。基于这些参数，本研究能够评估已知载荷下的动脉瘤应力状态，并为破裂标准的定义指明方向。
