Center for infectious Disease Epidemiology and Prevention Research, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, 183-8509, Japan.
School of Veterinary Medicine, Azabu University, Sagamihara, Kanagawa, 252-5201, Japan.
Arch Virol. 2024 Sep 16;169(10):200. doi: 10.1007/s00705-024-06120-5.
Novel bovine parechoviruses (Bo ParVs) were isolated from the feces of Japanese black cattle. Phylogenetic analysis revealed that the novel Bo ParVs formed an independent cluster, exhibiting 72.2-75.6% nucleotide sequence identity to previous Bo ParVs, suggesting that they represent a new genotype. Bo ParVs, including the novel Bo ParVs, shared sequence similarity with each other in the 3' untranslated region (3'UTR) and exhibited low sequence similarity (<38.9% identity) to other parechoviruses. However, a secondary structure prediction of the 3'UTR revealed that the Bo ParVs shared conserved motifs in domain 2 with parechovirus B and E, suggesting some evolutionary constrains in this region.
从日本黑牛的粪便中分离到了新型牛肠道细小病毒（Bo ParVs）。系统进化分析显示，新型 Bo ParVs 形成了一个独立的分支，与先前的 Bo ParVs 具有 72.2-75.6%的核苷酸序列同一性，提示它们代表了一个新的基因型。Bo ParVs 包括新型 Bo ParVs，在 3'非翻译区（3'UTR）中彼此具有序列相似性，与其他肠道细小病毒的序列相似性较低（<38.9%的同一性）。然而，3'UTR 的二级结构预测显示，Bo ParVs 在与肠道细小病毒 B 和 E 的结构域 2 中共享保守基序，提示该区域存在一些进化限制。
