Ström H, Dahlqvist S R, Bjelle A, Möller E
Hum Immunol. 1985 Aug;13(4):243-51. doi: 10.1016/0198-8859(85)90003-5.
Two three-generation families from Northern Sweden with rheumatoid arthritis (RA) were clinically examined. Tissue typing was performed for HLA-A, -B, -C, and -DR antigens. No disease-associated haplotype could be defined within these families. Six of nine members with RA were HLA-DR4 positive. Both families had a HLA-DR4 containing haplotype in the first generation and second-generation members married DR4 positive individuals, which probably increased the risk to develop RA in the third-generation members.
对来自瑞典北部的两个患有类风湿性关节炎（RA）的三代家庭进行了临床检查。对HLA - A、 - B、 - C和 - DR抗原进行了组织分型。在这些家庭中未发现与疾病相关的单倍型。9名患有RA的家庭成员中有6名HLA - DR4呈阳性。两个家庭的第一代和第二代成员都有一个含有HLA - DR4的单倍型，并且第二代成员与DR4呈阳性的个体结婚，这可能增加了第三代成员患RA的风险。
