人类白细胞抗原与类风湿关节炎。对五个家庭的研究。
HLA and rheumatoid arthritis. A study of five families.
作者信息
Ström H, Möller E
出版信息
Tissue Antigens. 1981 Aug;18(2):92-100. doi: 10.1111/j.1399-0039.1981.tb01370.x.
Abstract
Five families with two or more members ill with rheumatoid arthritis were investigated clinically. Tissue typing for HLA A, B, C and D/DR antigens was performed. We could not define may HLA haplotype associated with disease within these families. However, the prevalence of the haplotypes containing HLA-DR4 was high, suggesting a direct relationship between DR4 and increased risk of contracting rheumatoid arthritis.
摘要
对五个有两名或更多成员患类风湿性关节炎的家庭进行了临床调查。对 HLA A、B、C 和 D/DR 抗原进行了组织分型。在这些家庭中，我们无法确定与疾病相关的 HLA 单倍型。然而，含有 HLA-DR4 的单倍型的患病率很高，这表明 DR4 与患类风湿性关节炎风险增加之间存在直接关系。
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