Shibuya H, Takagi M, Horiuchi J, Suzuki S
Int J Radiat Oncol Biol Phys. 1985 Sep;11(9):1709-12. doi: 10.1016/0360-3016(85)90224-x.
Autopsy was performed on 67 patients who had squamous cell carcinoma of the maxillary sinus. These patients had undergone radiotherapy and died during a 30 year period, which ended for this study in 1982. The clinicopathological picture showed several differences according to changes of the mode of therapy and to the rise in local control rate. Postmortem examinations have shown a decreased death rate from extensive carcinoma, and increased distant metastases after the introduction of megavoltage irradiation and trimodal combination therapy (radiotherapy + surgery + intraarterial infusion of antimetabolites). In addition, the introduction of aggressive chemotherapy with antimetabolites and antibiotics has given rise to several gastrointestinal complications.
对67例上颌窦鳞状细胞癌患者进行了尸检。这些患者接受了放射治疗，并在30年期间死亡，本研究于1982年结束。临床病理情况根据治疗方式的变化和局部控制率的提高显示出一些差异。尸检显示，在采用兆伏放疗和三联综合治疗（放疗+手术+动脉内输注抗代谢药物）后，广泛癌的死亡率降低，但远处转移增加。此外，采用抗代谢药物和抗生素进行积极化疗引发了一些胃肠道并发症。
