Shibuya H, Horiuchi J, Suzuki S, Shioda S, Enomoto S
Int J Radiat Oncol Biol Phys. 1984 Jul;10(7):1021-6. doi: 10.1016/0360-3016(84)90173-1.
Four hundred and sixteen patients with carcinoma of the maxillary sinus received primary therapy consisting of external beam irradiation alone or in combination with surgery and/or chemotherapy at the Department of Radiology, Tokyo Medical and Dental University Hospital, between 1953 and 1982. In our institution, methods of treating cancer of the maxillary sinus have been changed from time to time and showed different control rates and clinical courses. An actuarial 10-year survival rate of 21% has been obtained by megavoltage irradiation alone as well as 34% actuarial 10-year survival rate by megavoltage irradiation with surgery. After the introduction of conservative surgery followed by conventional trimodal combination therapy (antrotomy: intraoral partial maxillectomy + radiation + intra-arterial infusion), the local control rate has been improved. The amount of functional, cosmetic, and brain damages have been remarkably decreased by this mode of therapy. The actuarial five year survival rate was 67%. In addition, along with the improvement of the local control rate, the control of nodal and distant organ metastases have been emerging as one of the important contributions to the prognosis of this disease.
1953年至1982年间，416例上颌窦癌患者在东京医科齿科大学医院放射科接受了单纯外照射或联合手术和/或化疗的初始治疗。在我们机构，治疗上颌窦癌的方法不断变化，显示出不同的控制率和临床病程。单纯兆伏级放疗的10年精算生存率为21%，兆伏级放疗联合手术的10年精算生存率为34%。在采用保守手术并结合传统三联综合治疗（鼻窦切开术：口腔内部分上颌骨切除术+放疗+动脉内灌注）后，局部控制率得到了提高。这种治疗方式显著减少了功能、美容和脑损伤。五年精算生存率为67%。此外，随着局部控制率的提高，淋巴结和远处器官转移的控制已成为影响该疾病预后的重要因素之一。
