Hosaka Y, Muramatsu M, Matsushima T, Niijima T, Nagase S
Jpn J Cancer Res. 1985 Jul;76(7):577-82.
The susceptibility of analbuminemic rats (Nagase analbuminemic rats; NAR) to induction of bladder cancer by oral N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT) was studied. Male NAR and Sprague-Dawley rats (SD) were fed normal diet or normal diet supplemented with 0.2% FANFT for 10 weeks and killed in week 52. Bladder cancer was found in 5 of 24 SD (21%) but not in 18 NAR (0%). Proliferative lesions of the bladder epithelium, which are considered to be precancerous or more advanced than precancerous changes, were found in 16 of 24 SD (67%), but in only 4 of 18 NAR (22%). NAR showed lower susceptibility than control SD to induction of bladder cancer by FANFT.
研究了无白蛋白血症大鼠（长谷川无白蛋白血症大鼠；NAR）经口服N-[4-(5-硝基-2-呋喃基)-2-噻唑基]甲酰胺（FANFT）诱导膀胱癌的易感性。雄性NAR大鼠和Sprague-Dawley大鼠（SD）被给予正常饮食或补充0.2% FANFT的正常饮食，持续10周，并在第52周处死。24只SD大鼠中有5只（21%）发生膀胱癌，但18只NAR大鼠中未发现（0%）。膀胱上皮的增殖性病变被认为是癌前病变或比癌前变化更严重的病变，在24只SD大鼠中有16只（67%）出现，但在18只NAR大鼠中只有4只（22%）出现。NAR大鼠对FANFT诱导膀胱癌的易感性低于对照SD大鼠。
