Laboratory of Veterinary Internal Medicine, Department of Veterinary Clinical Science, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea.
Haemaru Small Animal Clinical Research Institute, Seongnam, Republic of Korea.
Vet Med Sci. 2024 Sep;10(5):e70033. doi: 10.1002/vms3.70033.
BACKGROUND/AIM: The soluble interleukin-2 receptor (sIL-2R) serve as a valuable biomarker for tumors in human patients, as its levels increase during the activation of T lymphocytes in clinical states such as inflammation, infection, and tumor. This study aimed to demonstrate that sIL-2R levels can be also elevated in dogs with tumors and evaluate its applicability as a diagnostic and prognostic factor in canine cancer patients.
Serum was collected from 6 healthy dogs and 34 dogs with solid tumors. The concentration of sIL-2R was measured using a commercial enzyme-linked immunosorbent assay kit.
The median sIL-2R concentration was significantly higher in dogs with solid masses than in healthy dogs (117.3 vs 68.33 pg/ml, p = 0.016). The highest median sIL-2R concentration was found in dogs with malignant tumors, followed by those with benign tumors, and healthy dogs (119.6 vs 93.74 vs 68.33 pg/ml, respectively). In dogs with malignant tumors, the mortality rate was significantly higher in the group with high sIL-2R levels than in the group with low sIL-2R levels. Dogs with solid tumors, particularly those with malignant tumors, had higher concentrations of sIL-2R than healthy dogs. Among dogs with malignant tumors, a correlation between sIL-2R concentration and mortality rate was confirmed.
Serum sIL-2R levels may be used to detect malignant tumors and serve as a prognostic factor in dogs with malignant tumors.
背景/目的：可溶性白细胞介素-2 受体（sIL-2R）作为人类患者肿瘤的有价值的生物标志物，因为在炎症、感染和肿瘤等临床状态下，T 淋巴细胞的激活会导致其水平升高。本研究旨在证明 sIL-2R 水平也可在患有肿瘤的犬中升高，并评估其作为犬癌症患者的诊断和预后因素的适用性。
从 6 只健康犬和 34 只患有实体瘤的犬中采集血清。使用商业酶联免疫吸附测定试剂盒测量 sIL-2R 的浓度。
与健康犬相比，患有实体肿块的犬的 sIL-2R 浓度中位数显着升高（117.3 与 68.33 pg/ml，p=0.016）。恶性肿瘤犬的 sIL-2R 浓度中位数最高，其次是良性肿瘤犬，健康犬最低（119.6 与 93.74 与 68.33 pg/ml，分别）。在患有恶性肿瘤的犬中，高 sIL-2R 水平组的死亡率明显高于低 sIL-2R 水平组。患有实体肿瘤的犬，特别是患有恶性肿瘤的犬，sIL-2R 浓度高于健康犬。在患有恶性肿瘤的犬中，sIL-2R 浓度与死亡率之间存在相关性。
血清 sIL-2R 水平可用于检测恶性肿瘤，并可作为恶性肿瘤犬的预后因素。
