未保护的β-溴代苯胺与苄基、烷基、芳基、烯基和杂芳基硼酸酯的铃木-宫浦交叉偶联反应。
Suzuki-Miyaura cross-coupling of unprotected -bromoanilines with benzyl, alkyl, aryl, alkenyl and heteroaromatic boronic esters.
作者信息
Lubaev Alexandra E, Marvin Christopher C, Dombrowski Amanda W, Qureshi Zafar
机构信息
Department of Chemistry and Biochemistry, Baylor University Waco Texas 76706 USA.
AbbVie, Inc. 1 N. Waukegan Road North Chicago Illinois 60064 USA
出版信息
RSC Adv. 2024 Sep 16;14(40):29184-29188. doi: 10.1039/d4ra03725a. eCollection 2024 Sep 12.
Abstract
A Suzuki-Miyaura cross-coupling reaction was developed on unprotected -bromoanilines. This operationally simple reaction was developed for the diversification of glucocorticoid receptor modulators (GRMs), showed compatibility to various boronic esters featuring unique functionalities, and was demonstrated on a gram scale.
摘要
在未保护的溴代苯胺上开发了铃木-宫浦交叉偶联反应。该操作简单的反应是为糖皮质激素受体调节剂（GRM）的多样化而开发的，对具有独特功能的各种硼酸酯具有兼容性，并在克级规模上得到了验证。
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