Zheng Rui, Zhong Wenwen, Chai Muyuan, Shi Xuetao
National Engineering Research Centre for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, 510006, PR China.
School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510640, PR China.
Bioact Mater. 2024 Sep 3;42:194-206. doi: 10.1016/j.bioactmat.2024.08.039. eCollection 2024 Dec.
Men are particularly sensitive to penis size, especially those with a deformed or injured penis. This can lead to a strong desire for penis enlargement surgery. Given the ethical sensitivities of the penis, penile implants need to be developed with both efficacy and safety. In this study, a polyvinyl alcohol (PVA) patch for penile enlargement prepared via cyclic freeze‒thaw cycles and alkaline treatment. The PVA hydrogels treated with 5 M NaOH had the best mechanical properties and stability. A negative Poisson's ratio structure is incorporated into the design of the enlargement patch, which allows it to conform well to the deformation of the penis. In rabbit models, the enlarged patches can effectively enlarge the penis without degradation or fibrosis while maintaining long-term stability . This innovation not only provides a safe option for patients in need of penile enlargement but also promises to make a broader contribution to the field of dynamic tissue repair.
男性对阴茎大小格外敏感，尤其是那些阴茎畸形或受伤的男性。这可能导致他们对阴茎增大手术有强烈的需求。鉴于阴茎的伦理敏感性，阴茎植入物的研发需要兼顾有效性和安全性。在本研究中，通过循环冻融循环和碱处理制备了一种用于阴茎增大的聚乙烯醇（PVA）贴片。用5 M氢氧化钠处理的PVA水凝胶具有最佳的力学性能和稳定性。在增大贴片的设计中引入了负泊松比结构，使其能够很好地顺应阴茎的变形。在兔模型中，增大贴片可以有效增大阴茎，且不会降解或纤维化，同时保持长期稳定性。这项创新不仅为有阴茎增大需求的患者提供了一种安全选择，也有望在动态组织修复领域做出更广泛的贡献。
