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用于化妆品薄膜开发的年龄定制人工皮肤模型。

Age-tailored artificial skin model for cosmetic film development.

作者信息

Gonçalves Marta, Brito Sofia, Song Chaeyeon, Han Youngkyu, Bin Bum-Ho, Weon Byung Mook

机构信息

School of Chemical Engineering and Global Research Center for e-Chem Meditronic Systems, Sungkyunkwan University, Suwon, 16419, South Korea.

Research Center for Advanced Materials Technology, Sungkyunkwan University, Suwon, 16419, South Korea.

出版信息

Mater Today Bio. 2025 Feb 26;31:101618. doi: 10.1016/j.mtbio.2025.101618. eCollection 2025 Apr.

DOI:10.1016/j.mtbio.2025.101618
PMID:40104640
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11919402/
Abstract

Thin film deposition is essential in the cosmetic industry, where formulations such as foundations and concealers rely on uniform layer formation to conceal pores and texture irregularities for a natural and even appearance. However, variations in skin topography, influenced by factors such as aging, genetics, and environmental exposure, can significantly affect the behavior of these films. Aging, in particular, leads to increased skin roughness and wrinkles, creating challenges to achieve consistent cosmetic deposition in diverse age groups. This study investigates the impact of age-related topographical changes on cosmetic thin film deposition and introduces a model for standardized, age-specific evaluation of cosmetic performance. Using X-ray microtomography, we compare skin topography from a cohort of the Korean population segmented into young and aged groups. A PDMS-based model is then constructed using these skin topographies, and thin film deposition is assessed both on human-derived skin positives and on the assembled model. This approach demonstrates the potential of artificial skin models for the precise quantification and evaluation of film coverage. In addition, we propose an improved model that incorporates key factors such as skin porosity and sebum production to increase realism. By exploring the interactions between skin morphology and cosmetic behavior, this method offers valuable insights into optimizing formulations to meet the diverse needs of consumers.

摘要

薄膜沉积在化妆品行业至关重要,在该行业中,诸如粉底和遮瑕膏之类的配方依赖于形成均匀的涂层,以遮盖毛孔和质地不平整之处,从而呈现自然均匀的外观。然而,受衰老、遗传和环境暴露等因素影响,皮肤表面形貌的变化会显著影响这些薄膜的性能。尤其是衰老会导致皮肤粗糙度增加和出现皱纹,这给在不同年龄组中实现一致的化妆品沉积带来了挑战。本研究调查了与年龄相关的形貌变化对化妆品薄膜沉积的影响,并引入了一个用于对化妆品性能进行标准化、针对特定年龄评估的模型。我们使用X射线显微断层扫描技术,比较了一组分为年轻组和老年组的韩国人群的皮肤表面形貌。然后,利用这些皮肤表面形貌构建了一个基于聚二甲基硅氧烷(PDMS)的模型,并在源自人体的皮肤阳性样本和组装好的模型上评估薄膜沉积情况。这种方法展示了人工皮肤模型在精确量化和评估薄膜覆盖率方面的潜力。此外,我们提出了一个改进模型,该模型纳入了皮肤孔隙率和皮脂分泌等关键因素,以提高逼真度。通过探索皮肤形态与化妆品性能之间的相互作用,这种方法为优化配方以满足消费者的多样化需求提供了有价值的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/030e69574df0/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/4ac1d9908147/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/8f974fe7665f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/bcfee98f8129/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/d36ad525383c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/f3d166e78d4c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/431a45a05fda/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/a6adcafb2be0/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/99b6a40b4066/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/de6e4ea67be0/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/d648468d8ff1/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/030e69574df0/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/4ac1d9908147/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/8f974fe7665f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/bcfee98f8129/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/d36ad525383c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/f3d166e78d4c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/431a45a05fda/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/a6adcafb2be0/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/99b6a40b4066/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/de6e4ea67be0/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/d648468d8ff1/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/009b/11919402/030e69574df0/gr11.jpg

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Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control.锌缺乏与高尔基体应激之间与年龄相关的相互作用阻碍了微管依赖性细胞信号传导和表观遗传控制。
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