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通过间充质干细胞浸润水平鉴定和验证胶质母细胞瘤中潜在的预后生物标志物

Identification and validation of potential prognostic biomarkers in glioblastoma via the mesenchymal stem cell infiltration level.

作者信息

Wang Shengyu, Mao Senlin, Li Xiaofu, Yang Dan, Zhou Yinglian, Yue Hui, Li Bing, Li Wei, Li Chengyun, Zhang Xuemei

机构信息

Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Department of Magnetic Resonance Imaging, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

出版信息

Front Oncol. 2024 Sep 2;14:1406186. doi: 10.3389/fonc.2024.1406186. eCollection 2024.

DOI:10.3389/fonc.2024.1406186
PMID:39286023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11403407/
Abstract

AIMS

Mesenchymal stem cells (MSCs) are key components in promoting glioblastoma (GBM) progression. This study aimed to explore new therapeutic targets and related pathogenic mechanisms based on different MSCs infiltration levels in GBM patients.

METHODS

We estimated the relationship between cell infiltration and prognosis of GBM. Subsequently, key risk genes were identified and prognostic models were constructed by LASSO-Cox analysis. The risk genes were validated by five independent external cohorts, single-cell RNA analysis, and immunohistochemistry of human GBM tissues. TIDE analysis predicted responsiveness to immune checkpoint inhibitors in different risk groups.

RESULTS

The MSCs infiltration level was negatively associated with survival in GBM patients. LOXL1, LOXL4, and GUCA1A are key risk genes that promote GBM progression and may act through complex intercellular communication.

CONCLUSION

This research has provided a comprehensive study for exploring the MSCs infiltration environment on GBM progression, which could shed light on novel biomarkers and mechanisms involved in GBM progression.

摘要

目的

间充质干细胞（MSCs）是促进胶质母细胞瘤（GBM）进展的关键成分。本研究旨在基于GBM患者不同的MSCs浸润水平探索新的治疗靶点及相关致病机制。

方法

我们评估了GBM细胞浸润与预后之间的关系。随后，通过LASSO - Cox分析鉴定关键风险基因并构建预后模型。通过五个独立的外部队列、单细胞RNA分析以及人GBM组织的免疫组化对风险基因进行验证。TIDE分析预测不同风险组对免疫检查点抑制剂的反应性。

结果

MSCs浸润水平与GBM患者的生存率呈负相关。LOXL1、LOXL4和GUCA1A是促进GBM进展的关键风险基因，可能通过复杂的细胞间通讯发挥作用。

结论

本研究为探索MSCs浸润环境对GBM进展的影响提供了全面的研究，这可能为GBM进展中涉及的新生物标志物和机制提供线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/d49cc3263dc3/fonc-14-1406186-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/ba63da875b93/fonc-14-1406186-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/e7d435095e63/fonc-14-1406186-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/4ccff9af8813/fonc-14-1406186-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/05ae5ca8a1ac/fonc-14-1406186-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/9c10c381849c/fonc-14-1406186-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/f2bcac4df738/fonc-14-1406186-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/2fd91fec350c/fonc-14-1406186-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/d49cc3263dc3/fonc-14-1406186-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/ba63da875b93/fonc-14-1406186-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/e7d435095e63/fonc-14-1406186-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/4ccff9af8813/fonc-14-1406186-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/05ae5ca8a1ac/fonc-14-1406186-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/9c10c381849c/fonc-14-1406186-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/f2bcac4df738/fonc-14-1406186-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/2fd91fec350c/fonc-14-1406186-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3b3c/11403407/d49cc3263dc3/fonc-14-1406186-g008.jpg

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