尼日利亚东南部Nsukka地区汽车喷漆工人接触油漆中挥发性有机化合物（VOCs）含量的影响。
Effects of exposure to volatile organic compounds (VOCs) content from paint on automobile paint workers in Nsukka, South Eastern Nigeria.
作者信息
Ogbodo John Onyebuchi, Egba Simeon Ikechukwu, Ogbodo Chizaramekpere Grace, Onwurah Ikechukwu Emmanuel, Njoku Obioma Uzoma
机构信息
Department of Science Laboratory Technology University of Nigeria, Nsukka, Nigeria.
Department of Biochemistry, Research and Extension, Kampala International University, Uganda.
出版信息
Heliyon. 2024 Aug 27;10(17):e37015. doi: 10.1016/j.heliyon.2024.e37015. eCollection 2024 Sep 15.
BACKGROUND
Volatile organic compounds (VOCs) fume in the workplace can act as an inducing agent to many health disorders.
OBJECTIVES
This work investigated the effects of exposure to VOCs content from paint on the automobile paint workers in South Eastern Nigeria.
METHODS
A total of fifty (50) respondent participated in the study. Following the completion of informed consent form and well-structured questionnaire, blood samples were drawn and used for biochemical analysis.
RESULTS
The results of the haematological analysis showed a significant (p < 0.05) increase in white blood cell (WBC) cluster of differentiation 4 (CD4), and platelet (PLT), and a significant (p < 0.05) decrease in packed cell volume (PCV), hemoglobin (HB), lymphocytes (LYM) and eosinophil (EOS) of the exposed automobile paint workers compared to the control (unexposed workers). Results also showed significant (p < 0.05) increase in liver marker indices; alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (TB) and albumin (ALB) as well as significant (p < 0.05) decrease in Alkaline phosphatase (ALP), total protein (TP), direct bilirubin (DB). There was significant (p < 0.05) increase in urea, creatinine, potassium (K), uric acid and nitric oxide concentrations and decrease in sodium (Na) and bicarbonate (HCO) Again, results showed significant increase in Glutathione (GSH), and Glutathione peroxidase (GPx) and significant (p < 0.05) decrease in Superoxide dismutase (SOD) and Catalase (CAT). The Malondialdehyde MDA concentration showed varied significant (p < 0.05) difference based on ages. There was significant (p < 0.05) increase in luteinizing hormone (LH) and Follicle stimulating hormone (FSH), and significant (p < 0.05) decrease in the Testosterone (TET) concentrations of the exposed automobile paint workers compared to the unexposed workers.
CONCLUSIONS
Result of this study suggests a toxic outcome due to exposure to VOCs in spray paint workers.
背景
工作场所中的挥发性有机化合物（VOCs）烟雾可诱发多种健康问题。
目的
本研究调查了尼日利亚东南部汽车喷漆工人接触油漆中VOCs成分的影响。
方法
共有五十（50）名受访者参与了该研究。在完成知情同意书和结构完善的问卷后，采集血样并用于生化分析。
结果
血液学分析结果显示，与对照组（未接触的工人）相比，接触油漆的汽车喷漆工人的白细胞分化抗原4（CD4）、血小板（PLT）显著（p<0.05）增加，而红细胞压积（PCV）、血红蛋白（HB）、淋巴细胞（LYM）和嗜酸性粒细胞（EOS）显著（p<0.05）减少。结果还显示肝脏标志物指标显著（p<0.05）升高；丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、总胆红素（TB）和白蛋白（ALB），以及碱性磷酸酶（ALP）、总蛋白（TP）、直接胆红素（DB）显著（p<0.05）降低。尿素、肌酐、钾（K）、尿酸和一氧化氮浓度显著（p<0.05）升高，而钠（Na）和碳酸氢盐（HCO）降低。同样，结果显示谷胱甘肽（GSH）和谷胱甘肽过氧化物酶（GPx）显著增加，超氧化物歧化酶（SOD）和过氧化氢酶（CAT）显著（p<0.05）降低。丙二醛（MDA）浓度根据年龄显示出显著（p<0.05）差异。与未接触的工人相比，接触油漆的汽车喷漆工人的促黄体生成素（LH）和促卵泡生成素（FSH）显著（p<0.05）升高，睾酮（TET）浓度显著（p<0.05）降低。
结论
本研究结果表明喷漆工人接触VOCs会产生毒性后果。
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