Mao Qingsong, Zhu Xiaoyi, Kong Yuzhe
Hepatobiliary Pancreatic Surgery, Banan Hospital of Chongqing Medical University, Chongqing, China.
Xiangya School of Medicine, Central South University, Changsha, China.
Front Psychiatry. 2024 Sep 2;15:1455896. doi: 10.3389/fpsyt.2024.1455896. eCollection 2024.
This study investigates the association between heavy metal exposure and the prevalence of depression, with the mediating role of sleep duration.
Our study investigated the association between heavy metal concentration and depression risk in the NHANES from 2005 to 2020. We used logistic regression analysis, WQS regression model and BKMR model to assess the association. Mediation analysis was performed to explore the role of sleep duration in heavy metal exposure-induced depression.
Of the 10,825 individuals included in this study, 705 (6.85%) were diagnosed with depression. We found a positive association between the cadmium (Cd), cobalt (Co), lead (Pb), antimony (Sb), wolfram (W) concentration and the prevalence of depression. Moreover, heavy metals mixtures were positively correlated with the prevalence of depression, with Cd identified as the main contributor in the WQS regression model (0.4654). Furthermore, sleep duration mediated the association between Cd, molybdenum (Mo), Pb, Sb, W exposure and prevalence of depression, explaining 3.12%, 15.84%, 18.24%, 9.56%, 3.68% of the effect.
The findings affirm that heavy metal exposure is linked to higher depression incidence and that this relationship is partly mediated by sleep duration alterations. The study underscores the importance of environmental health monitoring and interventions aimed at reducing heavy metal exposure to mitigate its psychological impacts.
本研究探讨重金属暴露与抑郁症患病率之间的关联，以及睡眠时间的中介作用。
我们的研究调查了2005年至2020年美国国家健康与营养检查调查（NHANES）中重金属浓度与抑郁症风险之间的关联。我们使用逻辑回归分析、加权分位数和（WQS）回归模型以及贝叶斯核机器回归（BKMR）模型来评估这种关联。进行中介分析以探讨睡眠时间在重金属暴露诱发抑郁症中的作用。
本研究纳入的10825名个体中，705人（6.85%）被诊断为抑郁症。我们发现镉（Cd）、钴（Co）、铅（Pb）、锑（Sb）、钨（W）浓度与抑郁症患病率之间呈正相关。此外，重金属混合物与抑郁症患病率呈正相关，在WQS回归模型中Cd被确定为主要贡献因素（0.4654）。此外，睡眠时间介导了Cd、钼（Mo）、Pb、Sb、W暴露与抑郁症患病率之间的关联，分别解释了效应的3.12%、15.84%、18.24%、9.56%、3.68%。
研究结果证实重金属暴露与较高的抑郁症发病率有关，且这种关系部分由睡眠时间改变介导。该研究强调了环境卫生监测以及旨在减少重金属暴露以减轻其心理影响的干预措施的重要性。
