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儿科人群中1型糖尿病管理面临的基于年龄的挑战。

Age-based challenges to type 1 diabetes management in the pediatric population.

作者信息

Lan Yung-Yi, Kovinthapillai Rujith, Kędzia Andrzej, Niechciał Elżbieta

机构信息

Department of Pediatric Diabetes, Clinical Auxology and Obesity, Poznan University of Medical Sciences, Poznan, Poland.

出版信息

Front Pediatr. 2024 Sep 2;12:1434276. doi: 10.3389/fped.2024.1434276. eCollection 2024.

Abstract

Type 1 diabetes is rising in the pediatric population, affecting approximately 1.2 million children and adolescents globally. Its complex pathogenesis involves the interaction between genetic predisposition and environmental factors, leading to T cell-mediated destruction of insulin-producing pancreatic beta-cells. This destruction results in insulin insufficiency and hyperglycemia. Hence, managing type 1 diabetes requires a comprehensive approach that includes various aspects such as blood glucose monitoring, insulin therapy, carbohydrate counting, caloric intake monitoring, considering family habits and food preferences, planning daily schedules, and incorporating physical activity. Children with type 1 diabetes encounter age-specific challenges in disease management that may exacerbate the risk of metabolic complications and adverse health outcomes. These risk factors may be neurological, physiological, behavioral, psychological, or social, complicate management and necessitate tailored approaches for effective care. Regardless of the age group, primary caregivers have a high responsibility to maintain optimal glycemic control, including monitoring diet, daily activity, and administering insulin. By reviewing research on the challenges faced by pediatric patients with type 1 diabetes, we summarized key insights aimed at developing targeted interventions and support systems that enhance diabetes management and improve health outcomes in this vulnerable population.

摘要

1型糖尿病在儿科人群中的发病率正在上升,全球约有120万儿童和青少年受其影响。其复杂的发病机制涉及遗传易感性和环境因素之间的相互作用,导致T细胞介导的胰岛素分泌胰腺β细胞破坏。这种破坏会导致胰岛素分泌不足和高血糖。因此,管理1型糖尿病需要一种综合方法,包括血糖监测、胰岛素治疗、碳水化合物计数、热量摄入监测、考虑家庭习惯和食物偏好、规划日常日程以及进行体育活动等各个方面。1型糖尿病患儿在疾病管理中面临特定年龄的挑战,这可能会增加代谢并发症和不良健康结局的风险。这些风险因素可能是神经、生理、行为、心理或社会方面的,会使管理变得复杂,需要采取量身定制的方法进行有效护理。无论年龄组如何,主要照顾者都有高度责任维持最佳血糖控制,包括监测饮食、日常活动和注射胰岛素。通过回顾关于1型糖尿病儿科患者所面临挑战的研究,我们总结了关键见解,旨在开发有针对性的干预措施和支持系统,以加强糖尿病管理并改善这一弱势群体的健康结局。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e4/11402681/7900ef05f99c/fped-12-1434276-g001.jpg

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