Holder Shaniah S, Itama Ehizele P, Ikediashi Samuel N, Greaves Abigail, Malvan-Iyalla Alaerebo S, Hsu Frank
Medicine, American University of Barbados School of Medicine, Bridgetown, BRB.
Internal Medicine, Insight Hospital and Medical Center, Chicago, USA.
Cureus. 2024 Aug 14;16(8):e66854. doi: 10.7759/cureus.66854. eCollection 2024 Aug.
(), an opportunistic Gram-positive bacterium, is notorious for causing a plethora of clinical diseases. While it does not typically infect healthy skin, infections are prevalent in both community-acquired and hospital-acquired settings. Rheumatoid arthritis (RA), a chronic autoimmune disease characterized by joint inflammation and progressive bone erosion, can be managed medically and, in moderate to severe cases, surgically through arthroplasty. Complications of arthroplasty include wound infection, blood clots, stiffness, and infection around the prosthesis. Prosthetic joint infections (PJIs) are a rare complication of arthroplasty, commonly caused by aerobic Gram-positive bacteria. These infections can lead to bacteremia, precipitating a cascade of adverse clinical sequelae. This report aims to explore the etiology of delayed-onset PJIs, the underlying pathophysiology of this condition leading to bacteremia, the complications of bacteremia, and the management strategies employed to treat PJIs and complicated cases of bacteremia resulting from PJIs.
（）是一种机会性革兰氏阳性细菌，因引发多种临床疾病而声名狼藉。虽然它通常不会感染健康皮肤，但在社区获得性和医院获得性环境中感染都很普遍。类风湿性关节炎（RA）是一种以关节炎症和进行性骨侵蚀为特征的慢性自身免疫性疾病，可以通过药物治疗，在中度至重度病例中，还可通过关节成形术进行手术治疗。关节成形术的并发症包括伤口感染、血栓、僵硬以及假体周围感染。人工关节感染（PJI）是关节成形术的一种罕见并发症，通常由需氧革兰氏阳性细菌引起。这些感染可导致菌血症，引发一系列不良临床后果。本报告旨在探讨迟发性PJI的病因、导致菌血症的该病症潜在病理生理学、菌血症的并发症以及用于治疗PJI和由PJI引起的菌血症复杂病例的管理策略。
