使用布朗斯特酸/丁基三氟硼酸钾或电化学产生的酸对碳-碳三键进行二氟氟化反应。
-Difluorination of carbon-carbon triple bonds using Brønsted acid/BuNBF or electrogenerated acid.
作者信息
Yamaguchi Mizuki, Shimao Hiroki, Hamasaki Kengo, Nishiwaki Keiji, Kashimura Shigenori, Matsumoto Kouichi
机构信息
Department of Chemistry, School of Science and Engineering, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka 577-8502, Japan.
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi-osaka, Osaka, 577-8502, Japan.
出版信息
Beilstein J Org Chem. 2024 Sep 6;20:2261-2269. doi: 10.3762/bjoc.20.194. eCollection 2024.
-Difluorination of carbon-carbon triple bonds was conducted using Brønsted acids, such as TfNH and TfOH, combined with BuNBF as the fluorine source. The electrochemical oxidation of a BuNBF/CHCl solution containing alkyne substrates could also give the corresponding -difluorinated compounds ( method). The electrolysis method was also applicable for -difluorination of alkynes.
使用布朗斯特酸（如三氟甲磺酸铵和三氟甲磺酸）与丁基三氟硼酸钾作为氟源进行碳-碳三键的二氟代反应。含有炔烃底物的丁基三氟硼酸钾/氯仿溶液的电化学氧化也能得到相应的二氟代化合物（方法）。电解方法也适用于炔烃的二氟代反应。
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