功能化炔烃和联烯的无溶剂无金属区域选择性氢氟化反应：一种合成β-二氟化物的有效方法
Solventless and Metal-free Regioselective Hydrofluorination of Functionalized Alkynes and Allenes: An Efficient Protocol for the Synthesis of -Difluorides.
作者信息
Lu Zhichao, Bajwa Bhvandip S, Liu Shiwen, Lee Sheye, Hammond Gerald B, Xu Bo
机构信息
Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, USA
Department of Chemistry, California State University, Fresno, California, USA.
出版信息
Green Chem. 2019 Mar 21;21(6):1467-1471. doi: 10.1039/c8gc03876g. Epub 2019 Feb 15.
Abstract
The combination of two easily handled, highly acidic liquid HF complex reagents, DMPU-12HF and KHSO-13HF, generated a highly acidic fluorination system that facilitated exclusive Markovnikov addition of HF to widely functionalized alkynes, including alkyne tethered drugs, or allenes to produce -difluorides with high atom economy, and with an easy workup.
摘要
两种易于处理的高酸性液态HF络合试剂DMPU - 12HF和KHSO - 13HF相结合，产生了一种高酸性氟化体系，该体系有助于HF以马氏规则专一性地加成到广泛官能化的炔烃（包括炔烃连接的药物）或丙二烯上，以高原子经济性生成β-二氟化物，并且后处理简便。
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