Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.
Carl Zeiss Vision International GmbH, Aalen, Germany.
J Vis. 2024 Sep 3;24(9):13. doi: 10.1167/jov.24.9.13.
Contrast processing is suggested to interact with eye growth and myopia development. A novel contrast-reducing myopia control lens design decreases image contrast and was shown to slow myopia progression. Limited insights exist regarding neural visual processing following adaptation to image contrast reduction. This study investigated foveal neural contrast sensitivity in 29 young adults following a 30-minute adaptation to scattering using a Bangerter occlusion foil 0.8, +0.5-diopter defocus, and a clear lens control condition. Neural contrast sensitivity at its peak sensitivity of 6 cycles per degree was assessed before and after adaptation to the lens conditions, employing a unique interferometric system. Pre-adaptation measurements were averaged from six replicates and post-adaptation measurements by the first and last three of six replicates. The change in neural contrast sensitivity was largest for scattering across the first and last three post-adaptation measurements (+0.05 ± 0.01 logCS and +0.04 ± 0.01 logCS, respectively) compared with control and defocus (all +0.03 ± 0.01 logCS). For scattering, the observed increase of neural contrast sensitivity within the first three measurements differed significantly from the pre-adaptation baseline (p = 0.04) and was significantly higher compared with the control condition (p = 0.04). The sensitivity increases in the control and defocus conditions were not significant (all p > 0.05). As the adaptation effect diminished, no significant differences were found from baseline or between the conditions in the last three measurements (all p > 0.05). When post-adaptation neural contrast sensitivities were clustered into 25-second sequences, a significant effect was observed between the conditions, with only a significant relevant effect between control and scattering at 25 seconds (p = 0.04) and no further significant effects (all p > 0.05). The alteration in neural contrast sensitivity at peak sensitivity was most pronounced following adaptation to the scattering condition compared with defocus and control, suggesting that induced scattering might be considered for myopia control.
对比处理被认为与眼球生长和近视发展有关。一种新颖的降低对比度的近视控制镜片设计降低了图像对比度，并且已被证明可以减缓近视进展。然而，对于适应图像对比度降低后的神经视觉处理，我们的了解仍然有限。本研究通过使用邦格特眼罩（0.8 + 0.5 屈光度离焦）和透明镜片对照条件，对 29 名年轻人在 30 分钟的散射适应后，研究了中央凹的神经对比敏感度。在适应镜片条件前后，使用独特的干涉测量系统评估了神经对比敏感度在其 6 度/周期的峰值灵敏度处的情况。在适应前，通过六个重复的平均值测量，在适应后，通过六个重复的前三个和后三个的平均值测量。与对照和离焦（均为+0.03 ± 0.01 logCS）相比，散射在前三个和后三个测量中的神经对比敏感度变化最大（分别为+0.05 ± 0.01 logCS 和+0.04 ± 0.01 logCS）。对于散射，在前三个测量中观察到的神经对比敏感度的增加与适应前的基线有显著差异（p = 0.04），并且与对照条件相比显著更高（p = 0.04）。对照和离焦条件下的敏感度增加没有显著差异（均 p > 0.05）。随着适应效应的减弱，在最后三个测量中，与基线或与条件之间均未发现显著差异（均 p > 0.05）。当将后适应的神经对比敏感度聚类为 25 秒序列时，在条件之间观察到显著的效果，仅在控制和散射条件之间在 25 秒时观察到显著的相关效果（p = 0.04），并且没有进一步的显著效果（均 p > 0.05）。与离焦和对照相比，适应散射条件后神经对比敏感度在峰值敏感度处的变化最为明显，这表明诱导散射可能被考虑用于近视控制。
