Cong Xiaoda, Liu Gang, Liu Peilin, Zhao Lewei, Chen Shupeng, Li Xiaoqiang, Shen Jiajian, Ding Xuanfeng
Department of Radiation Oncology, Corewell Health William Beaumont Hospital, Royal Oak, Michigan, USA.
Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Appl Clin Med Phys. 2025 Jan;26(1):e14526. doi: 10.1002/acm2.14526. Epub 2024 Sep 17.
The aim of this study was to evaluate the feasibility and plan quality of spot-scanning proton arc therapy (SPArc) using a synchrotron-accelerator-based proton therapy system compared to intensity-modulated proton therapy (IMPT).
Five representative disease sites, including head and neck, lung, liver, brain chordoma, and prostate cancers, were retrospectively selected. Both IMPT and SPArc plans are generated with the HITACHI ProBEAT PBS system's minimum MU constraints and physics beam model. The SPArc plans are generated with 2.5° sampling frequency. The static delivery time was simulated based on the previously published synchrotron delivery sequence model, and the dynamic delivery time was simulated using a proton arc gantry mechanical model integrated with the synchrotron delivery sequence. Both dosimetric plan quality and delivery efficiency are evaluated.
A superior plan quality is reached compared with the IMPT plans generated for the same disease site. However, a relatively prolonged static and dynamic delivery time post new challenge, as static time increased by 49.22% and dynamic time 59.10% on average.
This study presents the first simulation results of delivering the SPArc plans using a synchrotron-accelerated proton therapy system. The result shows its feasibility and limitations, which could guide future development.
本研究旨在评估与强度调制质子治疗（IMPT）相比，使用基于同步加速器的质子治疗系统进行点扫描质子弧形治疗（SPArc）的可行性和计划质量。
回顾性选择五个具有代表性的疾病部位，包括头颈癌、肺癌、肝癌、脑脊髓膜瘤和前列腺癌。IMPT和SPArc计划均使用日立ProBEAT笔形束扫描（PBS）系统的最小MU约束和物理束模型生成。SPArc计划以2.5°的采样频率生成。基于先前发表的同步加速器输送序列模型模拟静态输送时间，并使用与同步加速器输送序列集成的质子弧形治疗床机械模型模拟动态输送时间。评估剂量计划质量和输送效率。
与为同一疾病部位生成的IMPT计划相比，达到了更高的计划质量。然而，在新的挑战下，静态和动态输送时间相对延长，静态时间平均增加49.22%，动态时间平均增加59.10%。
本研究展示了使用同步加速器加速质子治疗系统实施SPArc计划的首个模拟结果。结果显示了其可行性和局限性，可为未来发展提供指导。
