Rafiyan Mahdi, Tootoonchi Elham, Golpour Mahdieh, Davoodvandi Amirhossein, Reiter Russel J, Asemi Reza, Sharifi Mehran, Rasooli Manesh Sayyed Mehdi, Asemi Zatollah
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.
Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Feb;398(2):1265-1282. doi: 10.1007/s00210-024-03451-7. Epub 2024 Sep 17.
Gastric cancer (GC) is the third leading reason of death in men and the fourth in women. Studies have documented an inhibitory function of melatonin on the proliferation, progression and invasion of GC cells. MicroRNAs (miRNAs) are small, non-coding RNAs that play an important function in regulation of biological processes and gene expression of the cells. Some studies reported that melatonin can suppress the progression of GC by regulating the exosomal miRNAs. Thus, melatonin represents a promising potential therapeutic agent for subjects with GC. Herein, we evaluate the existing data of both in vivo and in vitro studies to clarify the molecular processes involved in the therapeutic effects of melatonin in GC. The data emphasize the critical function of melatonin in several signaling ways by which it may inhibit cancer cell proliferation, decrease chemo-resistance, induce apoptosis as well as limit invasion, angiogenesis, and metastasis. This review provides a resource that identifies some of the mechanisms by which melatonin controls GC enlargement. In light of the findings, melatonin should be considered a novel and testable therapeutic mediator for GC treatment.
胃癌（GC）是男性第三大死因，女性第四大死因。研究已证明褪黑素对GC细胞的增殖、进展和侵袭具有抑制作用。微小RNA（miRNA）是小的非编码RNA，在细胞生物学过程调控和基因表达中发挥重要作用。一些研究报道，褪黑素可通过调节外泌体miRNA来抑制GC进展。因此，褪黑素是GC患者一种有前景的潜在治疗药物。在此，我们评估体内和体外研究的现有数据，以阐明褪黑素在GC治疗作用中涉及的分子过程。这些数据强调了褪黑素在几种信号传导途径中的关键作用，通过这些途径它可能抑制癌细胞增殖、降低化疗耐药性、诱导凋亡以及限制侵袭、血管生成和转移。本综述提供了一种资源，可识别褪黑素控制GC扩大的一些机制。鉴于这些发现，褪黑素应被视为GC治疗的一种新型且可测试的治疗介质。
