Unit of Toxicology, Clinical Sciences Department, Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe, s/n., Las Palmas de Gran Canaria, Canary Islands, CP 35016, Spain.
Asociación Científica Psicodélica, Las Palmas de Gran Canaria, Canary Islands, Spain.
Vet Res Commun. 2024 Dec;48(6):4007-4014. doi: 10.1007/s11259-024-10542-6. Epub 2024 Sep 17.
Anxiety affects 14-20% of dogs. Pharmacological treatments often fail. Psychedelics have shown to be useful for anxiety and depression in humans, but their veterinary use remains unexplored. We aimed to determine the effects of low-dose 1-cyclopropionyl-d-lysergic acid diethylamide (1cp-LSD) administered in a single dose to a dog, to observe the effect and establish the safety of the substance. The patient was a 13-year-old female dog, weighing 13 kg, mixed breed, and spayed. A total of 5 µg was administered orally, equivalent to 0.38 µg/kg. The animal has had a history of separation related behavioral problems throughout her life. To objectively assess the degree of anxiety in the dog, a validated scale was utilized. The trial was scheduled at the house where the animal lives. The owner was present throughout the experience. Informed consent was obtained prior to the assay. The trial began at 12:15 p.m. on January 10, 2024, lasting for 5 and a half hours. The response to anxiety-inducing stimuli was equally anxious during the first two hours. From that point onwards, a significant change in the animal's behavior was observed, with no signs/mild signs of anxiety. The trial concluded without any adverse effects on the animal. The patient did not show signs of having a psychedelic experience. This is the first time that a study of this nature has been conducted and reported in the canine species. 1cp-LSD proved to be safe and exerted the desired effect on the animal's behavior, significantly reducing the patient's anxiety.
焦虑影响 14-20%的狗。药物治疗往往失败。迷幻剂已被证明对人类的焦虑和抑郁有效，但它们在兽医中的应用仍未得到探索。我们的目的是确定单剂量给予狗低剂量 1-环丙基-D-麦角酸二乙酰胺（1cp-LSD）的效果，观察该物质的效果并确定其安全性。患者是一只 13 岁的雌性狗，体重 13 公斤，混合品种，已绝育。总共给予 5µg，相当于 0.38µg/kg。该动物一生都有与分离相关的行为问题史。为了客观评估狗的焦虑程度，使用了经过验证的量表。试验安排在动物居住的家中进行。主人全程在场。在进行测定之前获得了知情同意。试验于 2024 年 1 月 10 日下午 12 点 15 分开始，持续了 5 个半小时。在头两个小时内，对引起焦虑的刺激的反应同样焦虑。从那时起，观察到动物行为发生了显著变化，没有焦虑迹象/轻度焦虑迹象。试验在没有对动物造成任何不良影响的情况下结束。患者没有表现出具有迷幻体验的迹象。这是首次在犬科动物中进行此类研究并报告。1cp-LSD 被证明是安全的，并对动物的行为产生了预期的效果，显著减轻了患者的焦虑。
