通过摄入脂质降低正常受试者丙戊酸盐诱导的高氨血症。

Decrease of valproate-induced hyperammonemia in normal subjects by lipid ingestion.

作者信息

Warter J M, Marescaux C, Hirsch E, Rumbach L, Micheletti G, Chabrier G, Imler M

出版信息

J Neurol Sci. 1985 Jul;69(3):285-90. doi: 10.1016/0022-510x(85)90140-6.

Abstract

Sodium valproate (VPA), a branched short-chain fatty acid, always causes a hyperammonemia of renal origin in fasting man. The intake of medium-length, straight-chain fatty acids abolishes the VPA-induced hyperammonemia, and VPA free fraction increases concomitantly. Accordingly, fatty acids could be useful in preventing and treating hyperammonemia-accompanied stuporous states which are complications of VPA medication.

摘要

丙戊酸钠（VPA）是一种支链短链脂肪酸，在空腹的人身上总会引发肾源性高氨血症。摄入中链直链脂肪酸可消除VPA诱导的高氨血症，同时VPA的游离部分会相应增加。因此，脂肪酸可能有助于预防和治疗作为VPA药物治疗并发症的伴有高氨血症的昏迷状态。