Spoelstra S K, Schoevers R A, Venema S D, Knegtering H
Addiction Care North Netherlands, Groningen, The Netherlands.
NHL Stenden University of Applied Sciences, Leeuwarden, The Netherlands.
Discov Ment Health. 2024 Sep 17;4(1):37. doi: 10.1007/s44192-024-00095-0.
Despite considerable efforts, tobacco use disorder persists as a significant public health issue. The effectiveness of current smoking cessation therapies is limited, leading to a growing interest in alternative treatment approaches such as psychedelics.
The aim of this review is to evaluate the scientific evidence regarding the role of psychedelics in smoking cessation.
To identify relevant literature on psychedelics and smoking cessation, a search was conducted in four academic literature databases PubMed, MEDLINE, PsycINFO, and Embase. Databases were searched from their inception up to March 24, 2024.
Out of the 1073 articles identified in databases, 8 publications (both clinical and non-clinical studies) met the inclusion criteria, of which a total of 4 publications originated from a single study. The majority of the studies focused on psilocybin (n = 7), for which supportive evidence was suggested for the treatment of tobacco use disorder. Additionally, research was conducted with other psychedelics for smoking cessation, such as ayahuasca, mescaline, peyote, lysergic acid diethylamide (LSD), lysergic acid amide (LSA) and (dimethyltryptamine (DMT), but the evidence base for these psychedelics is too small to draw definitive conclusions.
There is, although limited, evidence that psychedelics, in particular psilocybin, may offer a potential avenue for combating tobacco use disorder, though more research is needed to understand their effectiveness and safety fully.
尽管付出了巨大努力，但烟草使用障碍仍然是一个重大的公共卫生问题。目前戒烟疗法的效果有限，这使得人们对诸如迷幻药等替代治疗方法的兴趣日益浓厚。
本综述的目的是评估关于迷幻药在戒烟中作用的科学证据。
为了识别有关迷幻药和戒烟的相关文献，我们在四个学术文献数据库（PubMed、MEDLINE、PsycINFO和Embase）中进行了检索。检索时间范围为各数据库建库至2024年3月24日。
在数据库中识别出的1073篇文章中，有8篇出版物（包括临床和非临床研究）符合纳入标准，其中共有4篇出版物来自同一项研究。大多数研究集中在裸盖菇素（n = 7），有证据支持其用于治疗烟草使用障碍。此外，还对其他用于戒烟的迷幻药进行了研究，如死藤水、三甲氧苯乙胺、仙人球毒碱、麦角酸二乙胺（LSD）、麦角酰胺（LSA）和二甲基色胺（DMT），但这些迷幻药的证据基础过于薄弱，无法得出明确结论。
虽然证据有限，但有证据表明迷幻药，尤其是裸盖菇素，可能为对抗烟草使用障碍提供一条潜在途径，不过需要更多研究来全面了解它们的有效性和安全性。
