Qiu Shengnan, Shi Yanbin, Zang Hengchang, Sun Xiaochen, Wang Qingjie, Fu Xianglei, Shen Hua, Mo Fanyang, Zhang Yankun, Chen Xiangqin, Zhou Jiamin, Li Lian, Lin Guimei
Key Laboratory for Technology Research and Evaluation of Drug Products, School of Pharmaceutical Sciences, Cheeloo College of Medience, Shandong University, 44 Wenhuaxi Road, Jinan, Shandong Province, 250012, China.
School of Mechanical & Automotive Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250353, China.
NPJ Regen Med. 2024 Sep 17;9(1):22. doi: 10.1038/s41536-024-00368-w.
Local injection of anti-inflammatory drugs for osteoarthritis emerged as a promising administration in the clinic, and sustained-release dosage forms have great potential for future therapeutic applications. Controlling the response of patients only in the acute inflammatory phase is currently the focus of therapeutic interventions. To relieve acute pain in patients and to improve the long-term prognosis effect of osteoarthritis treatment, we designed a two-pronged approach in this research: an injectable double-layer microsphere containing a "nonsteroidal anti-inflammatory drug - macrophage polarizing factor" was constructed. The results indicated that microspheres could regulate the intra-articular environment by inhibiting local inflammatory cytokine production, promoting macrophage polarization to the M2-phenotype, and increasing the expression of cartilage repair factors. Polymers chosen could govern the biocompatibility of microspheres and control the release sequence of the two drugs. Injection of microspheres into the degenerative articular cavity of rats leads to suppressed inflammation and well-promoted cartilage regeneration.
局部注射抗炎药物治疗骨关节炎在临床上已成为一种有前景的给药方式，缓释剂型在未来治疗应用中具有巨大潜力。目前治疗干预的重点是仅在急性炎症期控制患者的反应。为缓解患者的急性疼痛并改善骨关节炎治疗的长期预后效果，我们在本研究中设计了一种双管齐下的方法：构建了一种含有“非甾体抗炎药 - 巨噬细胞极化因子”的可注射双层微球。结果表明，微球可通过抑制局部炎症细胞因子产生、促进巨噬细胞向M2表型极化以及增加软骨修复因子的表达来调节关节内环境。所选用的聚合物可控制微球的生物相容性并控制两种药物的释放顺序。将微球注射到大鼠退变的关节腔中可导致炎症抑制和软骨再生良好促进。
