沉默转录活跃的HIV储存库以改善治疗效果。
Silencing the transcriptionally active HIV reservoir to improve treatment outcomes.
作者信息
Prigann Julia, Tavora Rubens, Furler O'Brien Robert L, Schulze-Gahmen Ursula, Boehm Daniela, Roan Nadia R, Nixon Douglas F, Ndhlovu Lishomwa C, Valente Susana, Ott Melanie
机构信息
Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA, USA.
Department of Immunology and Microbiology, The Herbert Wertheim UF Scripps Research Institute for Biomedical Innovation and Technology, University of Florida, Jupiter, FL, USA.
出版信息
Nat Microbiol. 2024 Oct;9(10):2470-2472. doi: 10.1038/s41564-024-01816-5.
Abstract
Persistence of the transcriptionally active HIV reservoir (TAHR) has important implications for people living with HIV (PLWH), including chronic immune activation and inflammation. Supplementing antiretroviral therapy with HIV transcriptional inhibitors could overcome this by silencing the TAHR.
摘要
转录活性HIV储存库（TAHR）的持续存在对HIV感染者（PLWH）具有重要影响，包括慢性免疫激活和炎症。用HIV转录抑制剂补充抗逆转录病毒疗法可以通过使TAHR沉默来克服这一问题。
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