沉默转录活跃的HIV储存库以改善治疗效果。
Silencing the transcriptionally active HIV reservoir to improve treatment outcomes.
作者信息
Prigann Julia, Tavora Rubens, Furler O'Brien Robert L, Schulze-Gahmen Ursula, Boehm Daniela, Roan Nadia R, Nixon Douglas F, Ndhlovu Lishomwa C, Valente Susana, Ott Melanie
机构信息
Gladstone Institute of Virology, Gladstone Institutes, San Francisco, CA, USA.
Department of Immunology and Microbiology, The Herbert Wertheim UF Scripps Research Institute for Biomedical Innovation and Technology, University of Florida, Jupiter, FL, USA.
出版信息
Nat Microbiol. 2024 Oct;9(10):2470-2472. doi: 10.1038/s41564-024-01816-5.
Abstract
Persistence of the transcriptionally active HIV reservoir (TAHR) has important implications for people living with HIV (PLWH), including chronic immune activation and inflammation. Supplementing antiretroviral therapy with HIV transcriptional inhibitors could overcome this by silencing the TAHR.
摘要
转录活性HIV储存库（TAHR）的持续存在对HIV感染者（PLWH）具有重要影响，包括慢性免疫激活和炎症。用HIV转录抑制剂补充抗逆转录病毒疗法可以通过使TAHR沉默来克服这一问题。
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本文引用的文献
1
Plasma Human Immunodeficiency Virus 1 Soluble Glycoprotein 120 Association With Correlates of Immune Dysfunction and Inflammation in Antiretroviral Therapy-Treated Individuals With Undetectable Viremia.
J Infect Dis. 2024 Mar 14;229(3):763-774. doi: 10.1093/infdis/jiad503.
2
HIV silencing and cell survival signatures in infected T cell reservoirs.
Nature. 2023 Feb;614(7947):318-325. doi: 10.1038/s41586-022-05556-6. Epub 2023 Jan 4.
3
Phenotypic signatures of immune selection in HIV-1 reservoir cells.
Nature. 2023 Feb;614(7947):309-317. doi: 10.1038/s41586-022-05538-8. Epub 2023 Jan 4.
4
Forging a Functional Cure for HIV: Transcription Regulators and Inhibitors.
Viruses. 2022 Sep 7;14(9):1980. doi: 10.3390/v14091980.
5
Parallel analysis of transcription, integration, and sequence of single HIV-1 proviruses.
Cell. 2022 Jan 20;185(2):266-282.e15. doi: 10.1016/j.cell.2021.12.011. Epub 2022 Jan 12.
6
The XPB Subunit of the TFIIH Complex Plays a Critical Role in HIV-1 Transcription and XPB Inhibition by Spironolactone Prevents HIV-1 Reactivation from Latency.
J Virol. 2021 Feb 15;95(4). doi: 10.1128/JVI.01247-20. Epub 2020 Nov 25.
7
HIV-1 Transcription but Not Intact Provirus Levels are Associated With Systemic Inflammation.
J Infect Dis. 2021 Jun 4;223(11):1934-1942. doi: 10.1093/infdis/jiaa657.
8
Filgotinib suppresses HIV-1-driven gene transcription by inhibiting HIV-1 splicing and T cell activation.
J Clin Invest. 2020 Sep 1;130(9):4969-4984. doi: 10.1172/JCI137371.
9
Defective HIV-1 proviruses produce viral proteins.
Proc Natl Acad Sci U S A. 2020 Feb 18;117(7):3704-3710. doi: 10.1073/pnas.1917876117. Epub 2020 Feb 6.
10
Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines.
Nat Commun. 2018 Dec 13;9(1):5305. doi: 10.1038/s41467-018-07753-2.
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