Department of Hepatobiliary Surgery, Guangdong Provincial People's Hospital, Guangzhou, China.
Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
BMC Gastroenterol. 2024 Sep 17;24(1):317. doi: 10.1186/s12876-024-03412-7.
The impact of prior SARS-CoV-2 infection on postoperative recovery of patients who underwent liver resection for hepatocellular carcinoma (HCC) remains uncertain given the lack of sufficient evidence.
To investigate the impact of prior SARS-CoV-2 infection on postoperative recovery of patients who underwent liver resection for hepatocellular carcinoma (HCC).
Patients who were pathologically diagnosed with HCC and underwent elective partial hepatectomy in Guangdong Provincial People's Hospital between January 2022 and April 2023 were enrolled in this retrospective cohort study. The patients were divided into two groups based on their history of SARS-CoV-2 infection. Rehabilitation parameters, including postoperative liver function, incidence of complications, and hospitalization expenses, were compared between the two groups. Propensity score matching (PSM) was performed to reduce confounding bias.
We included 172 patients (58 with and 114 without prior SARS-CoV-2 infection) who underwent liver resection for HCC. No significant differences in the rehabilitation parameters were observed between the two groups. After PSM, 58 patients were selected from each group to form the new comparative groups. Similar results were obtained within the population after PSM.
Prior SARS-CoV-2 infection does not appear to affect postoperative rehabilitation, including liver function, postoperative complications, or hospitalization expenses among patients with HCC after elective partial hepatectomy.
由于缺乏足够的证据，先前的 SARS-CoV-2 感染对接受肝细胞癌 (HCC) 肝切除术患者术后恢复的影响仍不确定。
调查先前的 SARS-CoV-2 感染对接受肝细胞癌 (HCC) 肝切除术患者术后恢复的影响。
本回顾性队列研究纳入了 2022 年 1 月至 2023 年 4 月期间在广东省人民医院经病理诊断为 HCC 并接受择期部分肝切除术的患者。根据 SARS-CoV-2 感染史将患者分为两组。比较两组患者的术后肝功能、并发症发生率和住院费用等康复参数。采用倾向评分匹配（PSM）来减少混杂偏倚。
共纳入 172 例（58 例有和 114 例无先前 SARS-CoV-2 感染）接受 HCC 肝切除术的患者。两组患者的康复参数无显著差异。PSM 后，每组各选择 58 例患者组成新的比较组。PSM 后人群中也得到了相似的结果。
先前的 SARS-CoV-2 感染似乎不会影响 HCC 患者接受择期部分肝切除术后的术后康复，包括肝功能、术后并发症或住院费用。
