Preclinic and Osteoncology Unit, Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Scientific Directorate, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Obes Rev. 2024 Dec;25(12):e13833. doi: 10.1111/obr.13833. Epub 2024 Sep 17.
The adipose tissue is a complex organ that can play endocrine, metabolic, and immune regulatory roles in cancer. In particular, adipocytes provide metabolic substrates for cancer cell proliferation and produce signaling molecules that can stimulate cell adhesion, migration, invasion, angiogenesis, and inflammation. Cancer cells, in turn, can reprogram adipocytes towards a more inflammatory state, resulting in a vicious cycle that fuels tumor growth and evolution. These mechanisms are enhanced in obesity, which is associated with the risk of developing certain tumors. Diet, an exogenous source of lipids with pro- or anti-inflammatory functions, has also been connected to cancer risk. This review analyzes how adipocytes and lipids are involved in tumor development and progression, focusing on the relationship between obesity and cancer. In addition, we discuss how diets with varying lipid intakes can affect the disease outcomes. Finally, we introduce novel metabolism-targeted treatments and adipocyte-based therapies in oncology.
脂肪组织是一种复杂的器官，它在癌症中可以发挥内分泌、代谢和免疫调节作用。特别是，脂肪细胞为癌细胞增殖提供代谢底物，并产生可以刺激细胞黏附、迁移、侵袭、血管生成和炎症的信号分子。反过来，癌细胞可以使脂肪细胞向更具炎症状态重新编程，导致促进肿瘤生长和演变的恶性循环。这些机制在肥胖中得到增强，肥胖与某些肿瘤的发病风险相关。饮食是具有促炎或抗炎功能的脂质的外源性来源，也与癌症风险有关。本综述分析了脂肪细胞和脂质如何参与肿瘤的发生和发展，重点关注肥胖与癌症之间的关系。此外，我们还讨论了不同脂质摄入量的饮食如何影响疾病结局。最后，我们介绍了肿瘤学中基于代谢靶向治疗和脂肪细胞的治疗方法。
