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[儿童呼吸道感染性疾病实验室检测的新进展]

[New progress in laboratory detection of respiratory infectious diseases in children].

作者信息

Zhu K Y, Yuan F, Yang H O

机构信息

Department of Laboratory Medicine, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China Shanghai Key Laboratory of Embryo Original Diseases, Shanghai 200030, China Faculty of Medical Laboratory Science, College of Health Science and Technology, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China.

Department of Neurology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200062, China.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 2024 Sep 6;58(9):1458-1464. doi: 10.3760/cma.j.cn112150-20231221-00474.

Abstract

Respiratory infectious disease has become ahead of all the children's diseases, with the trend of continuously increasing global incidence, antimicrobial resistance and simultaneous infection with multiple pathogens. Diagnosis of this disease is mainly based on clinical symptoms and pathogenic detection. However, there are some differences in clinical manifestations, progression and prognosis between pediatric patients and adults, which prompting clinical diagnosis mainly depending on clinical laboratory test. Therefore, fast, convenient and accurate methods are urgently needed to clarify the type of infectious pathogen and carry out differentiated treatment, and reduce the burden on families and public health-care systems in schools. This article aims to elaborate the laboratory methods of children's respiratory infectious diseases and explore the opportunities and challenges, which can provide ideas for prevention, early screening and diagnosis, prognosis and treatment monitoring.

摘要

呼吸道传染病已成为所有儿童疾病之首,呈现出全球发病率持续上升、抗菌药物耐药性以及多种病原体同时感染的趋势。该疾病的诊断主要基于临床症状和病原体检测。然而,儿科患者与成人在临床表现、病情进展和预后方面存在一些差异,这促使临床诊断主要依赖临床实验室检查。因此,迫切需要快速、便捷且准确的方法来明确感染病原体的类型并进行差异化治疗,减轻家庭和学校公共卫生保健系统的负担。本文旨在阐述儿童呼吸道传染病的实验室检测方法,并探讨其中的机遇与挑战,为预防、早期筛查与诊断、预后及治疗监测提供思路。

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