Vrabec Tina L, Bhadra Niloy, Wainright Jesse S, Bhadra Narendra, Kilgore Kevin L
Case Western Reserve University 10900 Euclid Ave., Cleveland, Ohio 44106.
Case Western Reserve University 10900 Euclid Ave., Cleveland, Ohio 44106; MetroHealth Medical Center 2500 MetroHealth Dr Cleveland, OH 44109; and Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, 44106.
Int IEEE EMBS Conf Neural Eng. 2013 Nov;2013:283-286. doi: 10.1109/ner.2013.6695927.
Kilohertz frequency alternating current (KHFAC) has been shown to produce a fast acting, reversible nerve block. The principal drawback to this technique is a short, but intense burst of firing at the initiation of the KHFAC which is referred to as the "onset response". The "onset response" can be eliminated by the use of a second electrode which delivers direct current (DC) briefly during the onset duration. However, the DC cannot be delivered for a sufficiently long time to suppress the onset without causing damage to the nerve. High surface area electrodes have been developed which can be used to deliver DC for long enough to eliminate the onset without causing damage. Furthermore, instead of using multiple electrodes to create a no onset block, the DC and KHFAC are combined in novel waveform which can be output on a single monopolar electrode. This novel waveform has been demonstrated to prevent onset in both simulation and in an in vivo rat sciatic nerve model.
千赫兹频率交流电（KHFAC）已被证明能产生快速起效、可逆的神经阻滞。该技术的主要缺点是在KHFAC开始时会出现短暂但强烈的放电脉冲，这被称为“起始反应”。通过使用第二个电极在起始阶段短暂输送直流电（DC），可以消除“起始反应”。然而，直流电不能输送足够长的时间来抑制起始反应而不损伤神经。已开发出高表面积电极，可用于输送足够长时间的直流电以消除起始反应而不造成损伤。此外，不是使用多个电极来产生无起始反应的阻滞，而是将直流电和KHFAC组合成一种新型波形，该波形可在单个单极电极上输出。这种新型波形已在模拟实验和体内大鼠坐骨神经模型中被证明可防止起始反应。
