利用电波形实现周围神经的可逆性传导阻滞。
Reversible conduction block in peripheral nerve using electrical waveforms.
作者信息
Bhadra Niloy, Vrabec Tina L, Bhadra Narendra, Kilgore Kevin L
机构信息
Department of Physical Medicine & Rehabilitation, MetroHealth Medical Center, Cleveland, OH 44109, USA.
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
出版信息
Bioelectron Med (Lond). 2018 Jan;1(1):39-54. doi: 10.2217/bem-2017-0004. Epub 2017 Dec 14.
Abstract
INTRODUCTION
Electrical nerve block uses electrical waveforms to block action potential propagation.
MATERIALS & METHODS: Two key features that distinguish electrical nerve block from other nonelectrical means of nerve block: block occurs instantly, typically within 1 s; and block is fully and rapidly reversible (within seconds).
RESULTS
Approaches for achieving electrical nerve block are reviewed, including kilohertz frequency alternating current and charge-balanced polarizing current. We conclude with a discussion of the future directions of electrical nerve block.
CONCLUSION
Electrical nerve block is an emerging technique that has many significant advantages over other methods of nerve block. This field is still in its infancy, but a significant expansion in the clinical application of this technique is expected in the coming years.
摘要
引言
电神经阻滞利用电波形来阻断动作电位的传播。
材料与方法
电神经阻滞与其他非电神经阻滞方法相区别的两个关键特征：阻滞瞬间发生，通常在1秒内；且阻滞完全且迅速可逆（数秒内）。
结果
综述了实现电神经阻滞的方法，包括千赫兹频率交流电和电荷平衡极化电流。最后我们讨论了电神经阻滞的未来发展方向。
结论
电神经阻滞是一种新兴技术，与其他神经阻滞方法相比具有许多显著优势。该领域仍处于起步阶段，但预计未来几年该技术的临床应用将大幅扩展。
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本文引用的文献
1
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Int IEEE EMBS Conf Neural Eng. 2013 Nov;2013:283-286. doi: 10.1109/ner.2013.6695927.
2
Bioelectronic block of paravertebral sympathetic nerves mitigates post-myocardial infarction ventricular arrhythmias.电刺激脊柱旁交感神经减轻心肌梗死后室性心律失常。
Heart Rhythm. 2017 Nov;14(11):1665-1672. doi: 10.1016/j.hrthm.2017.06.025. Epub 2017 Jun 16.
3
Bioelectronic neuromodulation of the paravertebral cardiac efferent sympathetic outflow and its effect on ventricular electrical indices.椎旁心脏传出交感神经流出的生物电子神经调节及其对心室电指标的影响。
Heart Rhythm. 2017 Jul;14(7):1063-1070. doi: 10.1016/j.hrthm.2017.02.020. Epub 2017 Feb 20.
4
Modulation of activity and conduction in single dorsal column axons by kilohertz-frequency spinal cord stimulation.千赫兹频率脊髓刺激对单根背柱轴突活动和传导的调节作用。
J Neurophysiol. 2017 Jan 1;117(1):136-147. doi: 10.1152/jn.00701.2016. Epub 2016 Oct 19.
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