Xiong Weilin, Zhu Qingjun, Hu Xiaolei, Yuan Yehong, Zhao Yongwang, Jing Xiaoping, Guo Qingyin
Pediatric Hospital of the First affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China.
Department of Pediatrics, Henan University of Traditional Chinese Medicine, Zhengzhou, China.
Kidney Int Rep. 2024 Jul 6;9(9):2759-2766. doi: 10.1016/j.ekir.2024.07.003. eCollection 2024 Sep.
Immunoglobulin A vasculitis (IgAV) is related to chronic inflammation; however, little is known about the associations between IgAV and allergic rhinitis (AR) or chronic rhinosinusitis (CRS). We evaluated the relationships among IgAV, AR, and CRS in children.
The clinical data of children with IgAV who were hospitalized from January to December 2019 were analyzed retrospectively. Four groups were created, the simple AR, simple CRS, AR + CRS, and non-AR or non-CRS groups, to explore the relationships among IgAV, AR, and CRS.
We included 504 children with IgAV; and 357 (70.8%) were combined with AR or CRS, including 51 with simple AR, 70 with simple CRS, and 236 with AR + CRS. The incidences of renal involvement and recurrent rash were significantly higher in the simple AR group than in the non-AR or non-CRS group ( < 0.001). The incidences of renal involvement and recurrent rash were significantly higher in the AR + CRS group than in the non-AR or non-CRS group ( < 0.001). The incidences of renal involvement between the simple CRS group and non-AR or non-CRS group did not differ significantly, but that of recurrent rash was significantly higher than that in the other groups ( < 0.001). Age, abdominal pain, recurrent rash, simple AR, and AR combined with CRS were risk factors for renal involvement (all odds ratio [OR] > 1, < 0.05).
Chronic rhinitis may be related to the pathogenesis of IgAV, and AR or CRS may be the triggering factors of IgAV. AR may be a risk factor for renal involvement and recurrent rash in patients with IgAV.
免疫球蛋白A血管炎（IgAV）与慢性炎症相关；然而，关于IgAV与过敏性鼻炎（AR）或慢性鼻-鼻窦炎（CRS）之间的关联知之甚少。我们评估了儿童中IgAV、AR和CRS之间的关系。
回顾性分析2019年1月至12月住院的IgAV患儿的临床资料。创建了四组，即单纯AR组、单纯CRS组、AR + CRS组和非AR或非CRS组，以探讨IgAV、AR和CRS之间的关系。
我们纳入了504例IgAV患儿；其中357例（70.8%）合并AR或CRS，包括51例单纯AR、70例单纯CRS和236例AR + CRS。单纯AR组的肾脏受累和皮疹复发发生率显著高于非AR或非CRS组（P < 0.001）。AR + CRS组的肾脏受累和皮疹复发发生率显著高于非AR或非CRS组（P < 0.001）。单纯CRS组与非AR或非CRS组的肾脏受累发生率无显著差异，但皮疹复发发生率显著高于其他组（P < 0.001）。年龄、腹痛、皮疹复发、单纯AR以及AR合并CRS是肾脏受累的危险因素（所有比值比[OR] > 1，P < 0.05）。
慢性鼻炎可能与IgAV的发病机制有关，AR或CRS可能是IgAV的触发因素。AR可能是IgAV患者肾脏受累和皮疹复发的危险因素。
