Gupta Ruchi, Arora Ritu, Gupta Isha, Jain Parul
Department of Ophthalmology (Guru Nanak Eye Centre), Maulana Azad Medical College, New Delhi, India.
Indian J Ophthalmol. 2025 Jan 1;73(1):110-114. doi: 10.4103/IJO.IJO_24_24. Epub 2024 Sep 10.
To study tear film parameters and Meibomian glands in pediatric patients with vernal keratoconjunctivitis (VKC).
Forty-four eyes of 22 patients with VKC and 44 eyes of 22 age-matched controls were studied in a hospital-based cross-sectional study. Each subject underwent a complete ophthalmological examination including slit-lamp biomicroscopy, non-invasive break-up time (NIBUT), fluorescein break-up time (FBUT), corneal fluorescein staining, and Schirmer's test. Non-contact meibography was performed using a Sirius topographer.
All patients had VKC grades between 1 and 3 (Bonini scale). The mean NIBUT for cases was 8.83 ± 4.02 s and in controls, it was 15 ± 2.8 s ( P value < 0.001). The mean FBUT for cases was 9.41 ± 3.45 s and in controls, it was 16.7 ± 2.5 s ( P value < 0.001). Schirmer's values were 32 ± 3.1 mm in cases and 21.4 ± 4.1 mm in controls, which were significantly higher ( P value < 0.001). Also, 22.72% of the cases had corneal fluorescein staining in the form of superficial punctuate keratitis, whereas none of the control groups showed corneal staining. The examination of Meibomian glands using non-contact meibography showed a mean Meibomian gland dropout in the upper lid to be 29.7 ± 14.4% in VKC cases and 10.5 ± 3.2% in controls ( P value < 0.001). Meibography of the lower lid showed 25.9 ± 10.2% dropout in cases and 20.5 ± 6.1% in controls ( P value = 0.004).
Tear film parameters were significantly deranged in children with VKC in the active stage as compared to age-matched controls. Children with VKC also had a higher Meibomian gland dropout.
研究春季角结膜炎（VKC）患儿的泪膜参数及睑板腺情况。
在一项基于医院的横断面研究中，对22例VKC患者的44只眼和22例年龄匹配的对照者的44只眼进行了研究。每位受试者均接受了全面的眼科检查，包括裂隙灯生物显微镜检查、非侵入性泪膜破裂时间（NIBUT）、荧光素泪膜破裂时间（FBUT）、角膜荧光素染色和泪液分泌试验。使用Sirius地形图仪进行非接触式睑板腺造影。
所有患者的VKC分级均在1至3级之间（博尼尼量表）。病例组的平均NIBUT为8.83±4.02秒，对照组为15±2.8秒（P值<0.001）。病例组的平均FBUT为9.41±3.45秒，对照组为16.7±2.5秒（P值<0.001）。泪液分泌试验值病例组为32±3.1毫米，对照组为21.4±4.1毫米，病例组明显更高（P值<0.001）。此外，22.72%的病例有浅层点状角膜炎形式的角膜荧光素染色，而对照组均未出现角膜染色。使用非接触式睑板腺造影检查睑板腺发现，VKC病例上睑睑板腺缺失平均为29.7±14.4%，对照组为10.5±3.2%（P值<0.001）。下睑睑板腺造影显示病例组缺失25.9±10.2%，对照组为20.5±6.1%（P值=0.004）。
与年龄匹配的对照组相比，处于活动期的VKC患儿的泪膜参数明显紊乱。VKC患儿的睑板腺缺失也更多。
