Department of Neurology, Division of Life Sciences and Medicine, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC University of Science and Technology of China Hefei Anhui China.
Department of Neurology, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing China.
J Am Heart Assoc. 2024 Oct;13(19):e035225. doi: 10.1161/JAHA.124.035225. Epub 2024 Sep 18.
Cardiovascular diseases (CVDs) are a leading global health concern. Emerging evidence suggests a potential protective role of well-being in reducing CVD risk.
We conducted a cohort analysis using the UK Biobank data set, encompassing 121 317 participants. We assessed the well-being of participants using a well-being index derived from baseline questionnaires. Well-being categories were derived by latent class analysis using general happiness and satisfaction with family, friendships, health, and finance situations. The relationship between well-being and 4 major CVDs was analyzed using Cox proportional hazards models and Mendelian randomization. The study also examined the impacts of well-being on lifestyle factors and inflammatory markers, and its mediating role in the well-being-CVD relationship. Higher well-being was associated with a significantly reduced risk of various CVDs. Latent class analysis identified 4 distinct well-being groups (low, variable, moderate-to-high, and high satisfaction), with higher satisfaction levels generally associated with lower risk of CVDs. Mendelian randomization suggested potential causal relationships between well-being and reduced risk of CVDs. Participants with greater well-being demonstrated healthier behaviors and lower levels of inflammatory markers. Mediation analysis indicated that lifestyle and inflammatory markers partially mediated the relationship between well-being and CVDs.
This study demonstrates a robust inverse association between well-being and the risks of CVDs, suggesting that enhancing well-being may be a viable strategy for CVD prevention. The role of lifestyle factors and inflammation as a mediator provides insight into possible biological pathways linking psychological states and cardiovascular health.
心血管疾病（CVDs）是全球主要的健康关注点之一。新出现的证据表明，幸福感可能在降低 CVD 风险方面发挥着保护作用。
我们使用 UK Biobank 数据集进行了队列分析，该数据集包含 121317 名参与者。我们使用基于基线问卷的幸福感指数评估了参与者的幸福感。幸福感类别是通过潜在类别分析使用一般幸福感和对家庭、友谊、健康和财务状况的满意度来确定的。使用 Cox 比例风险模型和孟德尔随机化分析了幸福感与 4 种主要 CVD 之间的关系。该研究还检查了幸福感对生活方式因素和炎症标志物的影响，以及其在幸福感与 CVD 关系中的中介作用。更高的幸福感与各种 CVD 风险显著降低相关。潜在类别分析确定了 4 个不同的幸福感群体（低、可变、中至高和高满意度），一般来说，满意度越高，CVD 风险越低。孟德尔随机化表明幸福感与 CVD 风险降低之间存在潜在的因果关系。幸福感更高的参与者表现出更健康的行为和更低水平的炎症标志物。中介分析表明，生活方式和炎症标志物部分介导了幸福感与 CVD 之间的关系。
本研究表明幸福感与 CVD 风险之间存在稳健的负相关关系，提示增强幸福感可能是 CVD 预防的可行策略。生活方式因素和炎症作为中介的作用提供了关于将心理状态与心血管健康联系起来的可能生物学途径的见解。
