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运动通过改善线粒体稳态缓解心血管疾病。

Exercise Alleviates Cardiovascular Diseases by Improving Mitochondrial Homeostasis.

机构信息

School of Exercise and health Shanghai University of Sport Shanghai China.

出版信息

J Am Heart Assoc. 2024 Oct;13(19):e036555. doi: 10.1161/JAHA.124.036555. Epub 2024 Sep 18.

DOI:10.1161/JAHA.124.036555
PMID:39291488
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11681480/
Abstract

Engaging in regular exercise and physical activity contributes to delaying the onset of cardiovascular diseases (CVDs). However, the physiological mechanisms underlying the benefits of regular exercise or physical activity in CVDs remain unclear. The disruption of mitochondrial homeostasis is implicated in the pathological process of CVDs. Exercise training effectively delays the onset and progression of CVDs by significantly ameliorating the disruption of mitochondrial homeostasis. This includes improving mitochondrial biogenesis, increasing mitochondrial fusion, decreasing mitochondrial fission, promoting mitophagy, and mitigating mitochondrial morphology and function. This review provides a comprehensive overview of the benefits of physical exercise in the context of CVDs, establishing a connection between the disruption of mitochondrial homeostasis and the onset of these conditions. Through a detailed examination of the underlying molecular mechanisms within mitochondria, the study illuminates how exercise can provide innovative perspectives for future therapies for CVDs.

摘要

经常锻炼和进行身体活动有助于延缓心血管疾病（CVDs）的发生。然而，经常锻炼或身体活动对 CVDs 的益处的生理机制仍不清楚。线粒体动态平衡的破坏与 CVDs 的病理过程有关。运动训练通过显著改善线粒体动态平衡的破坏，有效地延迟 CVD 的发生和进展。这包括改善线粒体生物发生、增加线粒体融合、减少线粒体裂变、促进线粒体自噬以及减轻线粒体形态和功能。这篇综述全面概述了身体活动在 CVD 中的益处，将线粒体动态平衡的破坏与这些疾病的发生联系起来。通过对线粒体内部的潜在分子机制进行详细检查，该研究阐明了运动如何为 CVD 的未来治疗提供创新视角。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/689d/11681480/b49c474430de/JAH3-13-e036555-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/689d/11681480/85f211186156/JAH3-13-e036555-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/689d/11681480/46e82875eb40/JAH3-13-e036555-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/689d/11681480/2049a17e2587/JAH3-13-e036555-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/689d/11681480/1bd6989cf2b1/JAH3-13-e036555-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/689d/11681480/b49c474430de/JAH3-13-e036555-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/689d/11681480/85f211186156/JAH3-13-e036555-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/689d/11681480/46e82875eb40/JAH3-13-e036555-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/689d/11681480/2049a17e2587/JAH3-13-e036555-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/689d/11681480/1bd6989cf2b1/JAH3-13-e036555-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/689d/11681480/b49c474430de/JAH3-13-e036555-g004.jpg

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