Rudick R A, Peter D R, Bidlack J M, Knutson D W
Neurology. 1985 Oct;35(10):1443-9. doi: 10.1212/wnl.35.10.1443.
We found free light chains in the CSF of 18 MS patients, but not in any of 14 patients with other neurologic disease. CSF from all MS patients contained kappa and lambda chain dimers, less frequently contained light chain monomers, and never contained free gamma heavy chains. Light chains were not detected in matched serum samples. CSF from MS patients did not release free light chains from whole IgG in CSF of controls. The findings suggest that these free light chains originate in plasma cells, not from degradation of whole IgG.
我们在18例多发性硬化症（MS）患者的脑脊液中发现了游离轻链，但在14例患有其他神经系统疾病的患者中均未发现。所有MS患者的脑脊液中均含有κ和λ链二聚体，较少含有轻链单体，且从未含有游离γ重链。在匹配的血清样本中未检测到轻链。MS患者的脑脊液不会从对照脑脊液中的完整IgG释放游离轻链。这些发现表明，这些游离轻链起源于浆细胞，而非来自完整IgG的降解。
