Polena Helena, Fontbonne Arnaud, Abric Elise, Lecerf Guillaume, Chavagnac-Bonneville Marlène, Moga Alain, Ardiet Nathalie, Trompezinski Sandra, Sayag Michèle
Research and Development Department, NAOS Ecobiology Company, Aix-en-Provence, France.
NAOS Institute of Life Science, Aix-en-Provence, France.
J Cosmet Dermatol. 2024 Dec;23(12):4325-4333. doi: 10.1111/jocd.16529. Epub 2024 Sep 18.
Environmental factors are important in the generation or aggravation of sensitive skin syndrome (SSS). Creams can be useful for patients with SSS, particularly when triggering factors cannot be avoided. Several clinical studies have investigated the safety and efficacy of specific creams in patients with SSS, but the majority were assessed with a single type of triggering factor and were non-comparative. Therefore, this study's aim was to investigate, the benefit of a specific dermo-cosmetic product in response to physical and chemical factors in subjects with SSS.
Three clinical studies were performed on subjects presenting SSS. The physical impact was assessed in a stripping test, and in a randomized intra-individual study with a newly developed heat-cold stress model. To assess chemical factors, a capsaicin test on the nasolabial fold was performed.
The product significantly reduced the increase in skin microcirculation caused by stripping after 30 min versus. The untreated condition (45.8% vs. 62.0%; p < 0.01). Immediately and at D28, the product induced a significant increase in skin hydration even after a heat-cold stress, while the overall score of unpleasant symptoms significantly decreased compared with the control (8.1 vs. 10.7 and 3.7 vs. 8.0, respectively; p < 0.01). Regarding chemical factors, a significant difference in the sensation intensity (p < 0.001) was observed after capsaicin stress, also in terms of the sensation duration due to the product application versus the control (192 s vs. 403 s; p < 0.001).
These studies show that topical application of a dermo-cosmetic product can prevent unpleasant symptoms and improve the skin state in SSS exposed to physical and chemical triggering factors.
环境因素在敏感皮肤综合征（SSS）的发生或加重中起重要作用。面霜对SSS患者可能有用，尤其是在无法避免触发因素的情况下。多项临床研究调查了特定面霜对SSS患者的安全性和有效性，但大多数研究仅针对单一类型的触发因素进行评估，且缺乏对比。因此，本研究旨在探讨一种特定的皮肤美容产品对SSS受试者应对物理和化学因素的益处。
对患有SSS的受试者进行了三项临床研究。通过剥离试验和使用新开发的热冷应激模型进行的随机个体内研究评估物理影响。为评估化学因素，在鼻唇沟进行了辣椒素试验。
与未处理情况相比，该产品在30分钟后显著降低了剥离引起的皮肤微循环增加（45.8%对62.0%；p<0.01）。在热冷应激后，即使在第28天，该产品也能立即显著增加皮肤水分含量，同时与对照组相比，不愉快症状的总体评分显著降低（分别为8.1对10.7和3.7对8.0；p<0.01）。关于化学因素，在辣椒素应激后，在感觉强度方面观察到显著差异（p<0.001），在产品应用与对照相比的感觉持续时间方面也有显著差异（192秒对403秒；p<0.001）。
这些研究表明，局部应用皮肤美容产品可预防不愉快症状，并改善暴露于物理和化学触发因素的SSS患者的皮肤状态。
