Jia Jianru, Yang Huijuan, Zhang Zhen, Shi Haoxi, Chen Sisi, Shi Penghui, Fan Weiguang
Infection Division of the People's Hospital of Baoding, Baoding, Hebei China.
Clinical Laboratory of the People's Hospital of Baoding, Baoding, Hebei, China.
AIDS Res Hum Retroviruses. 2025 Jan;41(1):55-59. doi: 10.1089/AID.2024.0059. Epub 2024 Sep 27.
CRF01_AE and CRF07_BC are predominant circulating HIV-1 subtypes in China. In this study, we report two novel HIV-1 CRF01_AE/CRF07_BC recombinant forms isolated from one man who has sex with men (MSM) (BDD027) and one mother-to-child transmission (MTCT) case (BDL123) in Baoding City, Hebei Province, China. The recombination breakpoint analysis showed that the recombination pattern of the near-full-length genome of BDD027 consisted of two CRF07_BC fragments inserted into a CRF01_AE backbone, while the recombination pattern of the near-full-length genome of BDL123 consisted of one CRF01_AE fragment inserted into a CRF07_BC backbone. This study demonstrates the importance of strengthening the monitoring of HIV-1 molecular epidemiological characteristics and emphasizes the urgent need to reduce the HIV-1 epidemic among MSM and MTCT populations in China.
CRF01_AE和CRF07_BC是中国主要的流行HIV-1亚型。在本研究中，我们报告了从中国河北省保定市一名男男性行为者（MSM）（BDD027）和一例母婴传播（MTCT）病例（BDL123）中分离出的两种新型HIV-1 CRF01_AE/CRF07_BC重组形式。重组断点分析表明，BDD027近全长基因组的重组模式由插入CRF01_AE主干中的两个CRF07_BC片段组成，而BDL123近全长基因组的重组模式由插入CRF07_BC主干中的一个CRF01_AE片段组成。本研究证明了加强HIV-1分子流行病学特征监测的重要性，并强调了在中国男男性行为者和母婴传播人群中减少HIV-1流行的迫切需求。
