Karadeniz Technical University, Farabi Hospital, Department of Medical Oncology - Trabzon, Turkey.
Karadeniz Technical University, Farabi Hospital, Department of Medical Pathology - Trabzon, Turkey.
Rev Assoc Med Bras (1992). 2024 Sep 16;70(9):e20240398. doi: 10.1590/1806-9282.20240398. eCollection 2024.
Large cell neuroendocrine carcinoma of the lung is a rare type of lung cancer. There is a limited number of studies on clinical and histopathological characteristics that are effective in survival. The aim of this study was to investigate the relationship between histopathological and clinical characteristics, mainly Ki-67 proliferation index, and survival in patients diagnosed with large cell neuroendocrine carcinoma of the lung.
The data of 38 patients followed up with the diagnosis of large cell neuroendocrine carcinoma of the lung were evaluated. The mean Ki-67 value was determined to be 65.8% (±20.8). The patients' clinical characteristics and survival times were compared according to the cut-off value determined for Ki-67 index.
When median overall survival times were compared, it was seen that overall survival was numerically lower in patients aged 65 years and over, in tumors located on the right side, in cases who were in the metastatic stage at diagnosis, whose Ki-67 index was 65% and above, who did not receive chemotherapy, who did not undergo curative surgery, and in patients with chronic diseases (p>0.05). In the Kaplan-Meier analysis, the median overall survival was determined to be 22.2 months (95%CI 21.7-22.7) in the patients with Ki-67<65%, while it was found to be 20.3 months (95%CI 4.5-36.2) in the patients with Ki-67≥65% (p=0.351).
Our study identified subgroups with decreased survival in large cell neuroendocrine carcinoma of lung patients. Studies including a larger number of patients are needed to identify the prognostic importance of these clinical and histopathological characteristics.
肺大细胞神经内分泌癌是一种罕见的肺癌类型。目前关于对生存有影响的临床和组织病理学特征的研究数量有限。本研究旨在探讨肺大细胞神经内分泌癌患者的组织病理学和临床特征（主要是 Ki-67 增殖指数）与生存之间的关系。
评估了 38 例经诊断为肺大细胞神经内分泌癌患者的资料。Ki-67 平均值为 65.8%（±20.8）。根据 Ki-67 指数确定的截止值，比较患者的临床特征和生存时间。
当比较中位总生存时间时，我们发现 65 岁及以上的患者、肿瘤位于右侧的患者、诊断时处于转移阶段的患者、Ki-67 指数为 65%及以上的患者、未接受化疗的患者、未进行根治性手术的患者以及患有慢性病的患者的总体生存率较低（p>0.05）。在 Kaplan-Meier 分析中，Ki-67<65%的患者中位总生存期为 22.2 个月（95%CI 21.7-22.7），而 Ki-67≥65%的患者中位总生存期为 20.3 个月（95%CI 4.5-36.2）（p=0.351）。
本研究确定了肺大细胞神经内分泌癌患者中生存时间缩短的亚组。需要进行包括更多患者的研究，以确定这些临床和组织病理学特征的预后意义。
