Muş State Hospital, Department of Obstetrics and Gynecology - Muş, Turkey.
University of Health Sciences Turkey, Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Department of Obstetrics and Gynecology - İstanbul, Turkey.
Rev Assoc Med Bras (1992). 2024 Sep 16;70(9):e20240485. doi: 10.1590/1806-9282.20240485. eCollection 2024.
Endometriosis is a disease in which stromal cells and endometrial glands extend outside of the uterine cavity. Nevertheless, treatment failure and recurrence cause difficulties in management. This study aimed to evaluate the receptor-level components of bilateral endometriomas in the recurrence state.
Our retrospective cohort study was conducted with patients who underwent surgery for bilateral endometriomas between 2015 and 2021. In total, 113 patients were allocated. A total of 76 patients did not meet the eligibility criteria, and the data of 37 patients were evaluated. Medical treatments, recurrences, and postoperative follow-up data were collected. In archived tissue samples, measurements of progesterone receptor A and progesterone receptor B, histoscores and immunoreactivity scores, and their ratios were calculated in the group that received no postoperative medical treatment. Criteria for recurrence were a repeat operation and/or the detection of a new endometrioma>2 cm at the follow-up examination.
No recurrence was observed in 73.0% (n=27) of the cases, whereas recurrence was observed in 27.0% (n=10) of the participants. Patients without recurrence had significantly higher progesterone receptor B histoscore/progesterone receptor A histoscore and progesterone receptor B immunoreactivity score/progesterone receptor A immunoreactivity score results (p=0.01). Nevertheless, when the histoscores and immunoreactivity scores for both receptors were contrasted separately, there was no appreciable difference between them.
The dominance of progesterone receptor B over progesterone receptor A was inversely proportional to the recurrence status in bilateral endometriomas. Furthermore, our study revealed that assessing receptor levels alone did not result in a significant difference in recurrence.
子宫内膜异位症是一种间质细胞和子宫内膜腺体超出子宫腔外延伸的疾病。然而，治疗失败和复发导致管理困难。本研究旨在评估双侧卵巢子宫内膜异位症复发状态下的受体水平成分。
我们进行了一项回顾性队列研究，纳入了 2015 年至 2021 年间接受双侧卵巢子宫内膜异位症手术的患者。共有 113 名患者被分配。共有 76 名患者不符合入选标准，对 37 名患者的数据进行了评估。收集了患者的药物治疗、复发和术后随访数据。在存档的组织样本中，计算了未接受术后药物治疗的患者的孕激素受体 A 和孕激素受体 B 的测量值、组织学评分和免疫反应评分及其比值。复发的标准是重复手术和/或在随访检查中发现新的>2cm 的卵巢子宫内膜异位症囊肿。
73.0%（n=27）的病例无复发，27.0%（n=10）的患者出现复发。无复发患者的孕激素受体 B 组织学评分/孕激素受体 A 组织学评分和孕激素受体 B 免疫反应评分/孕激素受体 A 免疫反应评分结果显著更高（p=0.01）。然而，当单独比较两个受体的组织学评分和免疫反应评分时，两者之间没有明显差异。
在双侧卵巢子宫内膜异位症中，孕激素受体 B 相对于孕激素受体 A 的优势与复发状态呈反比。此外，我们的研究表明，单独评估受体水平不会导致复发率显著差异。
