Harnett W, Kusel J R, Barrowman M M
Parasite Immunol. 1985 Jul;7(4):415-28. doi: 10.1111/j.1365-3024.1985.tb00087.x.
An indirect radiolabelled antibody method has been developed to measure the effects of aldehydes on the amount of antigen detectable at the surface of adult male Schistosoma mansoni. Incubation of schistosomes in formaldehyde (0.01-10% wt/vol.) or glutaraldehyde (0.01-0.1% wt/vol.) was found to result in increased exposure of parasite antigens with a concomitant decrease in the amount of surface located host RBC antigens. Those concentrations of formaldehyde or glutaraldehyde which were most effective in removing or displacing host antigens were also most able to expose parasite antigens. These findings are consistent with the hypothesis that host antigens mask parasite antigens at the surface of the adult schistosome.
已开发出一种间接放射性标记抗体法，用于测量醛类对成年雄性曼氏血吸虫表面可检测到的抗原量的影响。发现将血吸虫置于甲醛（0.01 - 10%重量/体积）或戊二醛（0.01 - 0.1%重量/体积）中孵育，会导致寄生虫抗原的暴露增加，同时位于表面的宿主红细胞抗原量减少。那些在去除或取代宿主抗原方面最有效的甲醛或戊二醛浓度，也最能暴露寄生虫抗原。这些发现与宿主抗原掩盖成年血吸虫表面寄生虫抗原的假说一致。
