果蝇腺苷酸环化酶的遗传剖析
Genetic dissection of Drosophila adenylate cyclase.
作者信息
Livingstone M S
出版信息
Proc Natl Acad Sci U S A. 1985 Sep;82(17):5992-6. doi: 10.1073/pnas.82.17.5992.
Abstract
The Drosophila learning mutant rutabaga is missing calcium/calmodulin activation of adenylate cyclase (EC4.6.1.1). The mutation was mapped at a finer resolution to X chromosome bands 12F5-7. By comparing wild-type and mutant cyclase activities, the relative responsiveness of the calcium-sensitive and calcium-insensitive components to different ligands could be determined; the calcium-sensitive fraction of the total cyclase activity was significantly less responsive to guanyl nucleotides and monoamines. The results suggest that the component of cyclase activity that is stimulated by calcium/calmodulin, possibly a genetically distinct catalytic subunit, is not coupled to the G subunit or the G subunit/monoamine receptor complex.
摘要
果蝇学习突变体芜菁缺失腺苷酸环化酶（EC4.6.1.1）的钙/钙调蛋白激活。该突变以更高分辨率定位到X染色体的12F5 - 7带。通过比较野生型和突变型环化酶活性，可以确定钙敏感和钙不敏感成分对不同配体的相对反应性；总环化酶活性中钙敏感部分对鸟苷酸和单胺的反应性明显较低。结果表明，由钙/钙调蛋白刺激的环化酶活性成分，可能是一个基因上不同的催化亚基，不与G亚基或G亚基/单胺受体复合物偶联。
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