萝卜，一种巩固记忆缺陷的果蝇突变体。
Radish, a Drosophila mutant deficient in consolidated memory.
作者信息
Folkers E, Drain P, Quinn W G
机构信息
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
出版信息
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8123-7. doi: 10.1073/pnas.90.17.8123.
Abstract
We have characterized the behavior and genetics of the Drosophila mutant radish (rsh gene). Initial learning of radish flies in two olfactory discrimination tests is high, but subsequent memory decays rapidly at both early and late times after training. Anesthesia-resistant memory (consolidated memory) is undetectable in radish flies 3 hr after training. The mutant shows normal locomotor activity and normal sensitivity to the odor cues and electric-shock reinforcement used in the learning tests. The radish gene maps within a 180-kb interval in the 11D-E region of the X chromosome.
摘要
我们已经对果蝇突变体萝卜（rsh基因）的行为和遗传学特征进行了描述。在两项嗅觉辨别测试中，萝卜果蝇的初始学习能力很强，但在训练后的早期和晚期，随后的记忆都迅速衰退。训练3小时后，在萝卜果蝇中检测不到抗麻醉记忆（巩固记忆）。该突变体表现出正常的运动活性，并且对学习测试中使用的气味线索和电击强化具有正常的敏感性。萝卜基因定位于X染色体11D-E区域内180 kb的区间内。
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