Damas J, Bourdon V, Remacle-Volon G, Lecomte J
Prostaglandins Leukot Med. 1985 Jul;19(1):11-24. doi: 10.1016/0262-1746(85)90157-x.
Catechin dimers induce a large long-lasting oedema when injected in the paw of the rat. This oedema is not inhibited by methysergide, promethazine, indomethacin, phenidone, bromophenacyl bromide and colchicine. It is not modified in rats made leukopenic by methotrexate. It is slightly delayed in Brown Norway rats which were kallikrein-kininogen deficient. Similarly catechin dimers induce the formation of a large peritoneal exudate in the rat. The exudate contains insignificant levels of leucocytes and 5-hydroxytryptamine. It contains kinins but its PG content is very low. The exudate does not activate (14C)-arachidonic acid into PG. Catechin dimers induce kinin formation in rat plasma "in vitro". They inhibit the formation of PG and HETE-like compounds from (14C)-arachidonic acid by rat peritoneal cells "in vitro". Catechin dimers administered at sub-irritant doses reduced carrageenan-induced oedema. Catechin dimers at low doses have an anti-inflammatory effect which may depend on PG synthesis inhibition. At larger doses, they induce inflammatory responses which occur with almost complete lack of participation of PG.
儿茶素二聚体注射到大鼠爪部时会引起长时间的严重水肿。这种水肿不受甲基麦角新碱、异丙嗪、吲哚美辛、非那西丁、溴苯酰溴和秋水仙碱的抑制。在经甲氨蝶呤致白细胞减少的大鼠中，这种水肿没有改变。在缺乏激肽释放酶 - 激肽原的棕色挪威大鼠中，水肿稍有延迟。同样，儿茶素二聚体可诱导大鼠形成大量腹腔渗出液。渗出液中白细胞和5 - 羟色胺水平极低。其中含有激肽，但其前列腺素含量非常低。渗出液不会将（14C） - 花生四烯酸激活为前列腺素。儿茶素二聚体在“体外”可诱导大鼠血浆中激肽的形成。它们在“体外”抑制大鼠腹腔细胞由（14C） - 花生四烯酸形成前列腺素和类羟二十碳四烯酸化合物。以亚刺激剂量给药的儿茶素二聚体可减轻角叉菜胶诱导的水肿。低剂量的儿茶素二聚体具有抗炎作用，这可能取决于对前列腺素合成的抑制。大剂量时，它们会诱导炎症反应，且这种反应几乎完全不依赖前列腺素的参与。
