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Inflammation in the rat paw due to urate crystals. Involvement of the kinin system.

作者信息

Damas J, Remacle-Volon G, Adam A

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1984 Jan;325(1):76-9. doi: 10.1007/BF00507057.

DOI:10.1007/BF00507057
PMID:6709076
Abstract

Monosodium urate and uric acid crystals induced kinin formation in Wistar rat plasma. They were inactive in the Brown Norway rat plasma which did not contain high molecular weight kininogen and had a low level in prekallikrein. Crystal-induced inflammation in the Brown Norway rat paw developed later and reached only 70% of the values observed in Wistar rats. Captopril, a kininase inhibitor, enhanced the oedema induced in the Wistar rat but did not affect the oedema in the Brown Norway rat. The leucocyte accumulation in the peritoneal cavity after uric acid injection was similar in both strains. The kinin system appeared to be involved in the inflammatory process induced in the rat by urate and uric acid crystals, as it is involved in carrageenan oedema.

摘要

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1
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本文引用的文献

1
THE INFLAMMATORY PROCESS IN ACUTE GOUTY ARTHRITIS. I. ACTIVATION OF HAGEMAN FACTOR BY SODIUM URATE CRYSTALS.急性痛风性关节炎中的炎症过程。I. 尿酸钠晶体对激活因子的激活作用
J Lab Clin Med. 1965 Feb;65:307-15.
2
The effects of non-steroid anti-inflammatory drugs on leukocyte migration in carrageenin-induced inflammation.非甾体抗炎药对角叉菜胶诱导的炎症中白细胞迁移的影响。
Eur J Pharmacol. 1980 Aug 22;66(1):81-6. doi: 10.1016/0014-2999(80)90297-6.
3
Some acute inflammatory reactions in a strain of Brown-Norway rats which are deficient in kallikrein-kinin system.
几种肽酶抑制剂对P物质、辣椒素和胶原酶促炎作用的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1996 Nov;354(5):662-9. doi: 10.1007/BF00170843.
4
Bradykinin levels in inflammatory exudates.
Inflammation. 1985 Dec;9(4):419-24. doi: 10.1007/BF00916341.
5
Presence of T-kininogen and kinins in sponge-induced exudates in rats.大鼠海绵诱导渗出液中T-激肽原和激肽的存在
Br J Pharmacol. 1989 Aug;97(4):1343-9. doi: 10.1111/j.1476-5381.1989.tb12598.x.
在缺乏激肽释放酶-激肽系统的一种棕色挪威大鼠品系中发生的一些急性炎症反应。
Arch Int Pharmacodyn Ther. 1982 Dec;260(2):274-6.
4
Differences in prekallikrein and high molecular weight kininogen levels in two strains of Brown Norway rat (Kitasato strain and Katholiek strain).
Thromb Res. 1982 Oct 1;28(1):143-7. doi: 10.1016/0049-3848(82)90043-3.
5
Congenital deficiency in plasma kallikrein and kininogens in the brown Norway rat.棕色挪威大鼠血浆激肽释放酶和激肽原的先天性缺乏
Experientia. 1980 May 15;36(5):586-7. doi: 10.1007/BF01965817.
6
[Plasma prekallikrein deficiency in a strain of Brown Norway rats].[一种棕色挪威大鼠品系中的血浆前激肽释放酶缺乏症]
Arch Int Physiol Biochim. 1980 Dec;88(5):511-4. doi: 10.3109/13813458009092927.
7
Inflammatory process in acute gouty arthritis. 3. Vascular permeability-enhancing activity in normal human synovial fluid; induction by Hageman factor activators; and inhibition by Hageman factor antiserum.
J Lab Clin Med. 1967 Sep;70(3):372-83.
8
The presence of a kinin in inflammatory synovial effusion from arthritides of varying etiologies.不同病因关节炎所致炎性滑膜积液中激肽的存在情况。
Arthritis Rheum. 1967 Feb;10(1):13-20. doi: 10.1002/art.1780100103.
9
Crystal-induced inflammation in canine joints. II. Importance of polymorphonuclear leukocytes.犬关节中晶体诱导的炎症。II. 多形核白细胞的重要性。
J Exp Med. 1966 Jul 1;124(1):115-26. doi: 10.1084/jem.124.1.115.
10
Crystal induced inflammation in canine joints. 3. Evidence against bradykinin as a mediator of inflammation.
J Lab Clin Med. 1966 Sep;68(3):433-44.