Zhuo Mingxing, Fang Meiling, Yin Ying, Wang Jin, Wei Zhaoxia, Lu Jiaming, Jia Yegui
Department of Gastroenterology, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Wuhan, Hubei, China.
Eur J Gastroenterol Hepatol. 2025 Jan 1;37(1):39-46. doi: 10.1097/MEG.0000000000002847. Epub 2024 Sep 12.
Peptic ulcer disease (PUD) affects individuals aged ≥70 years globally, exerting a significant impact on their health and well-being. Understanding its epidemiological evolution and associated factors is crucial for guiding interventions and improving management.
This study utilized Global Burden of Disease Study data to examine the prevalence and temporal changes of PUD in individuals aged 70 years and older between 1990 and 2019. The analysis included assessing estimated annual percentage changes (EAPCs) to investigate temporal trends and regional variations.
Over the past 30 years, the number of individuals aged 70 years and above suffering from PUD globally has increased from 1 065 730 cases in 1990 to 1 608 463 cases in 2019. Despite an increasing number of cases, the prevalence of PUD among the elderly has exhibited a steady decline, with an EAPC of -1.47 (95% confidence interval: -1.57 to -1.37) over this timeframe. In 2019, the prevalence rates of PUD among individuals aged 70-74, 75-79, 80-84, and 85 years and older were 313.36, 365.77, 388.45, and 352.51 per 100 000 population, respectively. South Asia, high-income North America, and Central Sub-Saharan Africa were the regions with the highest prevalence rates of PUD in 2019, with rates of 624.90, 575.48, and 474.80 per 100 000 population, respectively. At the national level, Ireland, Australia, Brazil, Brunei Darussalam, and Bangladesh have effectively managed the burden of PUD among the elderly, achieving the greatest reduction. Additionally, regions with higher levels of socioeconomic development tended to have relatively lower burdens of PUD among the elderly, and prevalence rates varied across different regions and age groups.
Our study highlights the enduring burden of PUD among the global elderly population, emphasizing the significance of tailored interventions to address this pressing issue. This research underscores the critical need for targeted public health strategies aimed at improving outcomes specifically for older adults affected by PUD.
消化性溃疡病（PUD）在全球范围内影响着70岁及以上的人群，对他们的健康和福祉产生重大影响。了解其流行病学演变及相关因素对于指导干预措施和改善管理至关重要。
本研究利用全球疾病负担研究数据，调查了1990年至2019年间70岁及以上人群中PUD的患病率和时间变化。分析包括评估年度估计百分比变化（EAPCs）以研究时间趋势和区域差异。
在过去30年中，全球70岁及以上患有PUD的人数从1990年的1065730例增加到2019年的1608463例。尽管病例数有所增加，但老年人中PUD的患病率呈稳步下降趋势，在此期间EAPC为-1.47（95%置信区间：-1.57至-1.37）。2019年，70-74岁、75-79岁、80-84岁以及85岁及以上人群中PUD的患病率分别为每10万人口313.36例、365.77例、388.45例和352.51例。南亚、高收入的北美和撒哈拉以南非洲中部是2019年PUD患病率最高的地区，患病率分别为每10万人口624.90例、575.48例和474.80例。在国家层面，爱尔兰、澳大利亚、巴西、文莱达鲁萨兰国和孟加拉国有效控制了老年人中PUD的负担，降幅最大。此外，社会经济发展水平较高的地区老年人中PUD的负担往往相对较低，不同地区和年龄组的患病率有所不同。
我们的研究突出了全球老年人群中PUD的持续负担，强调了采取针对性干预措施解决这一紧迫问题的重要性。本研究强调了针对改善受PUD影响的老年人的结局制定有针对性的公共卫生策略的迫切需求。
