Department of General Practice, Jieyang People's Hospital, Jieyang, Guangdong, 522000, China.
Department of Rheumatology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, 515041, China.
BMC Public Health. 2024 Nov 27;24(1):3298. doi: 10.1186/s12889-024-20799-w.
Gout, an inflammatory arthritis, disproportionately affects the elderly due to hyperuricemia, leading to significant health-related quality of life impairments and escalating healthcare costs. However, a comprehensive global analysis focusing on the elderly population is needed to inform effective interventions.
Utilizing data from the Global Burden of Disease Study 2021, this study assessed the prevalence, incidence, and Years Lived with Disability (YLDs) of gout among individuals aged ≥ 55 years in 204 countries from 1990 to 2021. We also evaluated the impact of high body mass index (BMI) and kidney dysfunction as key risk factors.
The study identified 37,230,366 cases of gout globally among the elderly, with an age-standardized prevalence rate of 2505.4 per 100,000 population. There was a notable increase in prevalence with an Estimated Annual Percentage Change (EAPC) of 1.08. Similarly, the age-standardized incidence and YLD rates increased, with EAPCs of 0.83 and 1.06, respectively. High-income regions, particularly Australasia and High-income North America, exhibited the highest rates, while Central Latin America and the Caribbean reported the lowest. Males had a higher burden of gout than females. High BMI and kidney dysfunction were significant contributors to YLDs, with their impact more pronounced in regions with higher Socio-Demographic Index (SDI).
The study found a growing gout burden among the elderly, with substantial regional and gender disparities. It underscores the urgent need for targeted public health interventions, particularly in high SDI regions, to address modifiable risk factors like high BMI and kidney dysfunction and to curb the rising trend of gout prevalence and disability.
痛风是一种炎症性关节炎，由于高尿酸血症，老年人发病率较高，导致生活质量受到严重影响，医疗保健费用不断增加。然而，需要进行全面的全球分析，以了解老年人痛风的情况，从而制定有效的干预措施。
本研究利用 2021 年全球疾病负担研究的数据，评估了 204 个国家/地区 55 岁及以上人群痛风的患病率、发病率和残疾生活年（YLDs）。我们还评估了高身体质量指数（BMI）和肾功能障碍作为关键风险因素的影响。
研究发现，全球老年人群中有 37230366 例痛风病例，年龄标准化患病率为每 10 万人 2505.4 例。患病率呈显著上升趋势，估计年百分比变化（EAPC）为 1.08。同样，年龄标准化发病率和 YLD 率也呈上升趋势，EAPC 分别为 0.83 和 1.06。高收入地区，特别是澳大拉西亚和高收入北美地区，痛风发病率最高，而中拉丁美洲和加勒比地区发病率最低。男性痛风负担高于女性。高 BMI 和肾功能障碍是 YLDs 的重要原因，在社会人口指数（SDI）较高的地区影响更为明显。
研究发现，老年人群中痛风负担不断增加，存在显著的地区和性别差异。这突显了迫切需要采取有针对性的公共卫生干预措施，特别是在 SDI 较高的地区，以解决可改变的风险因素，如高 BMI 和肾功能障碍，并遏制痛风患病率和残疾率的上升趋势。
