Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec city, QC, Canada; CERVO Brain Research Centre, Quebec city, QC, G1J 2G3, Canada.
CERVO Brain Research Centre, Quebec city, QC, G1J 2G3, Canada; Department of Psychiatry and Neuroscience, Faculty of Medicine, Laval University, Quebec city, QC, Canada.
Psychiatry Res. 2020 Sep;291:113227. doi: 10.1016/j.psychres.2020.113227. Epub 2020 Jun 18.
Almost a third of the offspring of parents diagnosed with schizophrenia or bipolar disorder could develop a mental disorder or related symptoms. The objectives of this study were to test the existence of two distinct subgroups of youth at-risk, according to their retinal response to luminance measured with electroretinography (ERG), and to relate the resulting cluster memberships with the cognitive clusters previously reported.
A clustering analysis was performed with ERG measurements in 107 at-risk offspring. Each subgroup was compared to a healthy control group of 203 individuals. The ERG subgroup memberships were then associated with the cognitive clusters.
A two-cluster solution was obtained: HR-Cluster1 (n=53) showed a control-like ERG profile and HR-Cluster2 (n=54) showed reduced rod amplitudes and prolonged cone latencies of the b-wave. Subjects in the HR-Cluster2 were 2.7 times more likely to belong to the most detrimental cognitive subgroup than subjects in the HR-Cluster1 (49% Vs 18%).
At-risk offspring showed two distinct ERG profiles: a control-like and an altered profile. A higher risk of impaired cognitive function was observed in subjects with the altered ERG profile, suggesting the ERG as a potential biomarker of susceptibility to mental illness among youth at risk.
父母被诊断患有精神分裂症或双相情感障碍的子女中，几乎有三分之一可能会出现精神障碍或相关症状。本研究的目的是根据视网膜电图（ERG）测量的亮度反应，测试存在两个不同的高危青年亚组，并将由此产生的聚类成员与先前报道的认知聚类相关联。
对 107 名高危后代的 ERG 测量值进行聚类分析。每个亚组都与 203 名健康对照组进行比较。然后将 ERG 亚组成员与认知聚类相关联。
得到了一个两聚类的解决方案：HR-Cluster1（n=53）显示出类似对照的 ERG 图谱，HR-Cluster2（n=54）显示出减少的棒状振幅和延长的锥潜伏期的 b-波。与 HR-Cluster1 相比，HR-Cluster2 中的受试者更有可能属于最不利的认知亚组，比例为 2.7 比 18%（49%比 18%）。
高危后代表现出两种不同的 ERG 图谱：一种是对照样，另一种是改变样。改变的 ERG 图谱的受试者认知功能受损的风险更高，这表明 ERG 可能是高危青年易患精神疾病的潜在生物标志物。
