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羽扇豆醇:一种具有治疗潜力的膳食和药用三萜烯。

Lupeol: A dietary and medicinal triterpene with therapeutic potential.

机构信息

Jhargram Raj College, Jhargram 721507, India.

Maulana Azad College, Kolkata 700013, India.

出版信息

Biochem Pharmacol. 2024 Nov;229:116545. doi: 10.1016/j.bcp.2024.116545. Epub 2024 Sep 16.

DOI:10.1016/j.bcp.2024.116545
PMID:39293501
Abstract

Lupeol, a triterpene derived from various plants, has emerged as a potent dietary supplement with extensive therapeutic potential. This review offers a comprehensive examination of lupeol's applications across diverse health conditions. By meticulously analyzing current scientific literature, we have synthesized findings that underscore lupeol's impact on cancer, diabetes, gastrointestinal disorders, neurological diseases, dermatological conditions, nephrological issues, and cardiovascular health. The review delves into molecular studies that reveal lupeol's ability to modulate disease pathways and alleviate symptoms, positioning it as a promising therapeutic agent. Moreover, we discuss the potential role of lupeol in clinical practice and public health strategies, emphasizing its substantial benefits as a natural compound. This thorough analysis serves as a critical resource for researchers, providing insights into the multifaceted therapeutic properties of lupeol and its potential to significantly enhance health outcomes.

摘要

羽扇豆醇,一种从各种植物中提取的三萜烯,已成为一种具有广泛治疗潜力的强效膳食补充剂。本综述全面考察了羽扇豆醇在多种健康状况下的应用。通过仔细分析当前的科学文献,我们综合了研究结果,强调了羽扇豆醇对癌症、糖尿病、胃肠道疾病、神经疾病、皮肤状况、肾脏问题和心血管健康的影响。该综述深入探讨了分子研究,揭示了羽扇豆醇调节疾病途径和缓解症状的能力,将其定位为一种有前途的治疗剂。此外,我们还讨论了羽扇豆醇在临床实践和公共卫生策略中的潜在作用,强调了它作为一种天然化合物的巨大益处。这项全面的分析为研究人员提供了一个重要的资源,深入了解了羽扇豆醇的多方面治疗特性及其显著改善健康结果的潜力。

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Lupeol: A dietary and medicinal triterpene with therapeutic potential.羽扇豆醇:一种具有治疗潜力的膳食和药用三萜烯。
Biochem Pharmacol. 2024 Nov;229:116545. doi: 10.1016/j.bcp.2024.116545. Epub 2024 Sep 16.
2
Chemotherapeutic potential of lupeol against cancer in pre-clinical model: A systematic review and meta-analysis.羽扇豆醇在临床前模型中对癌症的化疗潜力:一项系统综述和荟萃分析。
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DSC and FTIR study on the interaction between pentacyclic triterpenoid lupeol and DPPC membrane.DSC 和 FTIR 研究五环三萜化合物羽扇豆醇与 DPPC 膜的相互作用。
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Beneficial health effects of lupeol triterpene: a review of preclinical studies.羽扇豆醇三萜的有益健康作用:临床前研究综述。
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Growth inhibition and apoptosis induced by lupeol, a dietary triterpene, in human hepatocellular carcinoma cells.羽扇豆醇,一种膳食三萜,诱导人肝癌细胞生长抑制和凋亡。
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Lupeol, an androgen receptor inhibitor, enhances the chemosensitivity of prostate cancer stem cells to antiandrogen enzalutamide-based therapy.羽扇豆醇,一种雄激素受体抑制剂,可增强前列腺癌干细胞对基于抗雄激素恩杂鲁胺治疗的化疗敏感性。
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Lupeol inhibits proliferation and induces apoptosis of human pancreatic cancer PCNA-1 cells through AKT/ERK pathways.羽扇豆醇通过AKT/ERK信号通路抑制人胰腺癌PCNA-1细胞的增殖并诱导其凋亡。
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Pentacyclic triterpenes of the lupane, oleanane and ursane group as tools in cancer therapy.五环三萜类化合物中的齐墩果烷、熊果烷和乌苏烷作为癌症治疗的工具。
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In vitro efficacy of different concentrations of lupeol on old world Leishmania donovani.不同浓度羽扇醇对旧大陆利什曼原虫的体外疗效。
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Lupeol Attenuates Oxysterol-Induced Dendritic Cell Activation Through NRF2-Mediated Antioxidant and Anti-Inflammatory Effects.羽扇豆醇通过NRF2介导的抗氧化和抗炎作用减轻氧化甾醇诱导的树突状细胞活化。
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An updated review deciphering the anticancer potential of pentacyclic triterpene lupeol and its nanoformulations.
一篇关于解读五环三萜羽扇豆醇及其纳米制剂抗癌潜力的最新综述。
Front Pharmacol. 2025 May 9;16:1594901. doi: 10.3389/fphar.2025.1594901. eCollection 2025.
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